Analytical Chemistry Department, Phytochemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India.
Nat Prod Res. 2023 Jun;37(12):2024-2030. doi: 10.1080/14786419.2022.2112957. Epub 2022 Aug 19.
subsp. (M.A. Rau) K.K. Khanna & An. Kumar (Orobanchaceae) is a parasitic plant indigenous to India. Locally, the plant is known as ' and . It is used to treat fever, piles, cardiovascular disorders, and blood-borne non-infectious diseases by ethnic communities. The phytochemical investigation of subsp. rhizome led to the isolation of azafrin (), rehmaionoside-C (), and mussaenoside (). Compounds ( and () are being reported for the first time from this plant. Compounds were evaluated for their intercellular glucose uptake activity in basal and insulin-TNF-α-stimulated L6 muscle cells. In particular, rehmaionoside C exhibited activity comparative to metformin, increasing uptake by basal- and insulin-TNF-αstimulated cells by 4.88- and 3.90-fold and 5.04- and 4.04-fold. While azafrin and mussaenoside have produced 3.03- and 2.36-fold; 4.03- and 3.22-fold increase in intercellular glucose uptake. Compounds did not show toxicities in rat L6 myoblast cells. The study suggests that rehmaionoside-C from subsp. might activate glucose uptake by insulin mimics and could be a nontoxic anti-diabetes lead for drug discovery.
（M.A. Rau）K.K. Khanna & An. Kumar（列当科）是一种原产于印度的寄生植物。在当地，这种植物被称为“和”。它被民族社区用于治疗发热、痔疮、心血管疾病和血液传播的非传染性疾病。对 亚种根茎的植物化学研究导致分离出了氮杂佛林（）、瑞马酮 C（）和麦萨诺苷（）。化合物（和（）是首次从该植物中报道的。对化合物进行了评价，以研究它们在基础状态和胰岛素-TNF-α刺激的 L6 肌肉细胞中的细胞间葡萄糖摄取活性。特别是，瑞马酮 C 表现出与二甲双胍相当的活性，使基础状态和胰岛素-TNF-α刺激的细胞的摄取分别增加了 4.88-和 3.90 倍和 5.04-和 4.04 倍。而氮杂佛林和麦萨诺苷分别产生了 3.03-和 2.36 倍；4.03-和 3.22 倍的细胞间葡萄糖摄取增加。化合物在大鼠 L6 成肌细胞中没有显示出毒性。该研究表明， 亚种中的瑞马酮 C 可能通过胰岛素模拟物激活葡萄糖摄取，并且可能是一种无毒的抗糖尿病药物发现先导化合物。
