Community Medicine Training Program: Medical Education, Hamad Medical Corporation, Doha, Qatar.
Division of Health Care Sciences, Center for Clinical Research and Management Education Dresden International University, Dresden, Germany.
Medicine (Baltimore). 2022 Aug 19;101(33):e29959. doi: 10.1097/MD.0000000000029959.
Successful recruitment of participants into clinical research has always been challenging and is affected by many factors. This systematic review aimed to explore the perceptions and attitudes as well as identify the factors affecting the participation in clinical research among the Eastern Mediterranean Regional Office countries' population.
A systematic search of the literature was conducted to explore attitudes or perceptions of the general public or patients towards participation in clinical research. PubMed, Pro-Quest Central, World Health Organizations Index Medicus for the Eastern Mediterranean Region, and Google Scholar were searched. Studies were considered eligible for inclusion if they presented primary data and were conducted in one of the Eastern Mediterranean Regional Office countries. A data extraction sheet was used to record the following: year, country, aim, population, sample size, study design, data collection, and setting. The identified factors from the included studies were categorized into motivators and barriers.
In total, 23 original research articles were identified that addressed perceptions or attitudes towards clinical research participation. Six main motivators and barriers of research participation among patients, the general public, and patient family members were identified. The most common cited motivators included personal benefits to the individual, altruism and the desire to help others, the research process, the influence of the physician, family encouragement, and religion. Concerns regarding safety, confidentiality, and other factors in addition to the research process, lack of trust in healthcare providers or healthcare system, lack of interest in research and no perceived personal benefit, religious concerns, and family/cultural concerns were the most cited barriers to participation.
The identified motivators and barriers are essential to tackle during clinical research planning among the population of Eastern Mediterranean Regional Office countries. Further research is needed to assess the attitudes and perceptions of individuals approached to participate in trials.
成功招募参与者参与临床研究一直具有挑战性，并受到许多因素的影响。本系统评价旨在探讨东地中海区域国家人口对参与临床研究的看法和态度，以及确定影响参与临床研究的因素。
系统检索文献，以探讨普通公众或患者对参与临床研究的态度或看法。检索了 PubMed、ProQuest Central、世界卫生组织东地中海区域医学索引和 Google Scholar。如果研究报告了原始数据，并且在东地中海区域的一个国家进行，则认为符合纳入标准。使用数据提取表记录以下内容：年份、国家、目的、人群、样本量、研究设计、数据收集和设置。从纳入的研究中确定的因素分为促进因素和障碍因素。
共确定了 23 篇原始研究文章，这些文章涉及对参与临床研究的看法或态度。确定了患者、普通公众和患者家属参与研究的 6 个主要促进因素和障碍因素。最常提到的促进因素包括个人受益、利他主义和帮助他人的愿望、研究过程、医生的影响、家庭鼓励和宗教。除了研究过程之外，对安全性、保密性和其他因素的担忧、对医疗保健提供者或医疗保健系统的缺乏信任、对研究缺乏兴趣和没有个人受益、宗教担忧以及家庭/文化担忧是参与研究的最大障碍。
确定的促进因素和障碍因素对于东地中海区域国家的人口进行临床研究规划至关重要。需要进一步研究来评估接近参与试验的个人的态度和看法。
