Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University.
School of Medicine Information Engineering, Guangzhou University of Chinese Medicine.
Future Microbiol. 2022 Oct;17:1231-1240. doi: 10.2217/fmb-2021-0247. Epub 2022 Aug 19.
We aimed to study the possible relationship between cryptococcal meningitis (CM) and HLA genotypes in HIV-negative immunocompetent patients. HLA of 53 HIV-negative immunocompetent Han Chinese CM patients were compared with those in 481 healthy individuals. We found a significant association between DQB105:02 and CM patients compared with controls. There were no significant differences in the frequencies of HLA alleles between CM with and without postinfectious inflammatory response syndrome and controls. Correlation analysis showed DQB105:02 was correlated with susceptibility to CM. CM patients carrying the DQB1*05:02 allele had more severe focal neurological deficit, higher initial modified Rankin Scale and British Medical Research Council staging scores. This study provides the first evidence for the interaction between specific HLA class II alleles and HIV-negative immunocompetent CM patients.
我们旨在研究隐球菌性脑膜炎（CM）与 HIV 阴性免疫功能正常患者 HLA 基因型之间可能存在的关系。将 53 例 HIV 阴性免疫功能正常的汉族 CM 患者的 HLA 与 481 例健康个体进行比较。与对照组相比，我们发现 DQB105:02 与 CM 患者之间存在显著关联。CM 患者与感染后炎症反应综合征患者和对照组之间 HLA 等位基因的频率无显著差异。相关性分析表明 DQB105:02 与 CM 的易感性相关。携带 DQB1*05:02 等位基因的 CM 患者具有更严重的局灶性神经功能缺损、更高的初始改良 Rankin 量表和英国医学研究理事会分期评分。这项研究首次提供了特定 HLA Ⅱ类等位基因与 HIV 阴性免疫功能正常 CM 患者相互作用的证据。
