Wang Anni, Liu Jia, Liu Junyu, Su Zhihui, Yao Shiqi, Yang Lu, Fan Liuxu, Ngai Iok Keng, Xu Xiaofeng, Jiang Ying, Peng Fuhua
Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Med Mycol. 2023 Apr 3;61(4). doi: 10.1093/mmy/myad040.
Oxidative imbalances have been observed in various neurological diseases. Despite the microbiological control in cryptococcal meningitis (CM), a proportion of previously healthy patients experience a clinical deterioration known as post-infectious inflammatory response syndrome (PIIRS). However, the antioxidant status in PIIRS remains unclear. In this study, we found that the serum antioxidant status of HIV-negative immunocompetent CM patients during PIIRS episodes was lower than that of healthy controls. There was a relationship between baseline serum indirect bilirubin levels and the development of PIIRS, and serum uric acid levels may indicate the severity of the disease during PIIRS episodes. Oxidative stress may play a role in the development of PIIRS.
在各种神经系统疾病中均观察到氧化失衡。尽管对隐球菌性脑膜炎（CM）进行了微生物学控制，但仍有一部分先前健康的患者会出现一种称为感染后炎症反应综合征（PIIRS）的临床恶化情况。然而，PIIRS中的抗氧化状态仍不清楚。在本研究中，我们发现HIV阴性免疫功能正常的CM患者在PIIRS发作期间的血清抗氧化状态低于健康对照组。基线血清间接胆红素水平与PIIRS的发生之间存在关联，并且血清尿酸水平可能表明PIIRS发作期间疾病的严重程度。氧化应激可能在PIIRS的发生中起作用。
