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死于未被察觉的急性髓系白血病:一种不寻常的法医诊断。

Death due to unsuspected acute myeloid leukaemia: an unusual forensic diagnosis.

作者信息

Krebs-Drouot Lila, Karpathiou Georgia, Scolan Virginie, Bidat-Callet Carolyne, Boyer Baptiste, Péoc'h Michel

机构信息

Forensic Medicine Department, Grenoble Alpes University Hospital, La Tronche, Grenoble, France.

Pathology Department, University Hospital of Saint-Etienne, Saint-Etienne, France.

出版信息

Forensic Sci Med Pathol. 2023 Mar;19(1):60-66. doi: 10.1007/s12024-022-00516-y. Epub 2022 Aug 19.

DOI:10.1007/s12024-022-00516-y
PMID:35984604
Abstract

Acute myeloid leukaemia (AML) is a rare haematologic cancer with a rapid increase in blast cells, which need to be rapidly diagnosed and treated. The aim of this report is to analyse the rare phenomenon of AML diagnosed at autopsy after sudden death. We report three cases of AML and perform a literature review using the mesh terms "sudden death" and "leukaemia". We report the cases of three young women diagnosed with AML only after autopsy. We found seven articles which reported sudden death due to AML diagnosed at autopsy. Diagnosis of AML during autopsy is rare but can raise forensic issues. A complete autopsy with pathology analysis is needed.

摘要

急性髓系白血病(AML)是一种罕见的血液系统癌症,其原始细胞迅速增加,需要迅速诊断和治疗。本报告的目的是分析猝死后经尸检确诊的AML这一罕见现象。我们报告了3例AML病例,并使用“猝死”和“白血病”等主题词进行了文献综述。我们报告了3名年轻女性仅在尸检后才被诊断为AML的病例。我们发现7篇文章报道了尸检时诊断出的AML导致的猝死。尸检期间诊断出AML很罕见,但可能引发法医问题。需要进行完整的尸检并进行病理分析。

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本文引用的文献

1
Clinical Characteristics and Treatment Outcomes of Childhood Acute Promyelocytic Leukemia in Korea: A Nationwide Multicenter Retrospective Study by Korean Pediatric Oncology Study Group.韩国儿童急性早幼粒细胞白血病的临床特征和治疗结果:韩国儿科肿瘤研究组的一项全国性多中心回顾性研究。
Cancer Res Treat. 2022 Jan;54(1):269-276. doi: 10.4143/crt.2021.313. Epub 2021 Apr 20.
2
Sudden Unexpected Death in a Child From Acute Myeloid Leukemia.儿童急性髓系白血病致突发意外死亡。
Am J Forensic Med Pathol. 2021 Jun 1;42(2):174-177. doi: 10.1097/PAF.0000000000000667.
3
Cerebrovascular manifestations in hematological diseases: an update.
血液系统疾病的脑血管表现:最新进展。
J Neurol. 2021 Sep;268(9):3480-3492. doi: 10.1007/s00415-021-10441-9. Epub 2021 Feb 13.
4
Unexpected infant death secondary to a pulmonary infiltration due to acute myelocytic leukaemia.急性髓细胞白血病继发肺部浸润导致的意外婴儿死亡。
Malays J Pathol. 2017 Aug;39(2):193-196.
5
Sudden Death Due to Cerebral Leukemic Hemorrhage in a 32-Year-Old Woman Who Had a Short-Term Benzene Exposure History.一名有短期苯接触史的32岁女性因脑白血病出血猝死。
Am J Forensic Med Pathol. 2016 Jun;37(2):60-3. doi: 10.1097/PAF.0000000000000226.
6
Risk factors and causes of sudden noncardiac death: A nationwide cohort study in Denmark.非心源性猝死的风险因素及病因:丹麦一项全国性队列研究
Heart Rhythm. 2015 May;12(5):968-74. doi: 10.1016/j.hrthm.2015.01.024. Epub 2015 Jan 19.
7
Sudden cardiac death as the presentation of acute myeloid leukaemia.以心脏性猝死为表现的急性髓系白血病
Br J Haematol. 2012 Nov;159(4):384. doi: 10.1111/bjh.12056. Epub 2012 Sep 13.
8
Sudden cardiac arrest and death following application of shocks from a TASER electronic control device.使用 TASER 电子控制装置电击后发生心脏骤停和死亡。
Circulation. 2012 May 22;125(20):2417-22. doi: 10.1161/CIRCULATIONAHA.112.097584. Epub 2012 Apr 30.
9
Undiagnosed, untreated acute promyelocytic leukemia presenting as a suspicious sudden death.未诊断、未治疗的急性早幼粒细胞白血病表现为可疑的猝死。
J Forensic Sci. 2012 May;57(3):829-31. doi: 10.1111/j.1556-4029.2012.02053.x. Epub 2012 Jan 31.
10
Sudden adult death.成人猝死。
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