From the Department of Pathology, Wake Forest Baptist Health, Winston Salem, NC.
Am J Forensic Med Pathol. 2021 Jun 1;42(2):174-177. doi: 10.1097/PAF.0000000000000667.
Acute myeloid leukemia can rarely cause sudden, unexpected death in children. Presentation may be non-specific and death may occur in children with no prior medical history. Herein we present the case of a previously healthy 2-year and 2 month-old White girl, who on autopsy, was found to have acute myeloid leukemia with KMT2A rearrangement extensively involving all major thoracic and abdominal organs. This case is presented to the forensic community to discuss the presentation and findings in sudden death caused by acute leukemia. The case highlights when acute leukemia should enter the differential as a potential cause of death, as well as potential resources available in the postmortem workup of acute leukemias.
急性髓系白血病在儿童中很少导致突然的、意外的死亡。其表现可能不具有特异性，并且可能发生于没有既往病史的儿童。本文报道了一例此前健康的 2 岁 2 个月大的白人女孩，尸检时发现患有急性髓系白血病伴 KMT2A 重排，广泛累及所有主要的胸腹部器官。本病例旨在向法医界介绍急性白血病导致猝死的表现和发现，讨论其作为潜在死亡原因的鉴别诊断，以及急性白血病死后检查中潜在的可用资源。
