T细胞受体Vβ基因家族与主要组织相容性复合体限制的相关性
Correlation of T cell receptor V beta gene family with MHC restriction.
作者信息
Morel P A, Livingstone A M, Fathman C G
出版信息
J Exp Med. 1987 Aug 1;166(2):583-8. doi: 10.1084/jem.166.2.583.
Abstract
We have studied a panel of DBA/2 T cell clones specific for sperm whale myoglobin (SpW Mb) for TCR (T cell receptor) beta chain gene expression by FACS analysis using the monoclonal antibodies F23.1 and KJ16 specific for the V beta 8 family of the TCR beta chain genes. Within any given specificity group, all the clones tested came from different mice. 10 of 11 I-Ed-restricted SpW Mb-specific T cell clones were F23.1+; 8 of these were also KJ16+. Only one of the three I-Ad-restricted clones tested was F23.1+; this clone was KJ16 negative. This study has demonstrated that I-Ed-restricted T cell clones from DBA/2 mice express members of the TCR V beta 8 family irrespective of the epitopes of SpW Mb recognized. These data suggest an apparent correlation between TCR V beta expression and MHC restriction.
摘要
我们使用针对TCR（T细胞受体）β链基因Vβ8家族的单克隆抗体F23.1和KJ16，通过流式细胞术分析，研究了一组针对抹香鲸肌红蛋白（SpW Mb）的DBA/2 T细胞克隆的TCR β链基因表达情况。在任何给定的特异性组中，所有测试的克隆均来自不同的小鼠。11个I-Ed限制性SpW Mb特异性T细胞克隆中有10个为F23.1阳性；其中8个也是KJ16阳性。测试的3个I-Ad限制性克隆中只有1个为F23.1阳性；该克隆为KJ16阴性。这项研究表明，来自DBA/2小鼠的I-Ed限制性T细胞克隆表达TCR Vβ8家族成员，而与所识别的SpW Mb表位无关。这些数据表明TCR Vβ表达与MHC限制之间存在明显的相关性。
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本文引用的文献
1
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J Exp Med. 1984 Aug 1;160(2):452-71. doi: 10.1084/jem.160.2.452.
2
Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition.抗原诱导的、H-2限制的、产生白细胞介素-2的T细胞杂交瘤。缺乏独立的抗原和H-2识别。
J Exp Med. 1981 May 1;153(5):1198-214. doi: 10.1084/jem.153.5.1198.
3
Binding of immunogenic peptides to Ia histocompatibility molecules.免疫原性肽与Ia组织相容性分子的结合。
Nature. 1985;317(6035):359-61. doi: 10.1038/317359a0.
4
Antigenic competition at the level of peptide-Ia binding.肽-Ia结合水平上的抗原竞争
Proc Natl Acad Sci U S A. 1986 Jun;83(12):4509-13. doi: 10.1073/pnas.83.12.4509.
5
Genes of the T-cell antigen receptor in normal and malignant T cells.正常和恶性T细胞中T细胞抗原受体的基因
Annu Rev Immunol. 1987;5:585-620. doi: 10.1146/annurev.iy.05.040187.003101.
6
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Nature. 1986;324(6098):679-82. doi: 10.1038/324679a0.
7
Correlations between T-cell specificity and the structure of the antigen receptor.T细胞特异性与抗原受体结构之间的相关性。
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