Klavinskis L S, Oldstone M B
J Gen Virol. 1987 Jul;68 ( Pt 7):1867-73. doi: 10.1099/0022-1317-68-7-1867.
Although viral infection has been suspected as the cause of some thyroid disorders, there has been limited data to support this contention seriously. Now we report the first evidence that lymphocytic choriomeningitis virus can persist in the thyroid gland, particularly thyroid epithelial cells in which thyroglobulin (Tg) the precursor of thyroid hormone, is synthesized. Concomitant with the infection of these cells is a significant reduction in Tg mRNA and in the level of circulating thyroid hormones. Another virus (lactate dehydrogenase virus) that causes persistent infection but does not replicate in the thyroid gland failed to alter levels of circulating thyroid hormones. These observations in an experimental model support the hypothesis that viruses may account for some thyroid disorders in man.
尽管病毒感染一直被怀疑是某些甲状腺疾病的病因，但严重支持这一论点的数据一直有限。现在我们报告首个证据，即淋巴细胞性脉络丛脑膜炎病毒可在甲状腺中持续存在，尤其是在合成甲状腺激素前体甲状腺球蛋白（Tg）的甲状腺上皮细胞中。伴随着这些细胞的感染，Tg mRNA和循环甲状腺激素水平显著降低。另一种引起持续感染但不在甲状腺中复制的病毒（乳酸脱氢酶病毒）未能改变循环甲状腺激素水平。在实验模型中的这些观察结果支持了病毒可能是人类某些甲状腺疾病病因的假说。
