用淋巴细胞性脉络丛脑膜炎病毒假型化的逆转录病毒载体。
Retroviral vectors pseudotyped with lymphocytic choriomeningitis virus.
作者信息
Miletic H, Bruns M, Tsiakas K, Vogt B, Rezai R, Baum C, Kühlke K, Cosset F L, Ostertag W, Lother H, von Laer D
机构信息
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, 20251 Hamburg, Germany.
出版信息
J Virol. 1999 Jul;73(7):6114-6. doi: 10.1128/JVI.73.7.6114-6116.1999.
Abstract
Pseudotyping can improve retroviral vector stability and transduction efficiency. Here, we describe a novel pseudotype of murine leukemia virus packaged with lymphocytic choriomeningitis virus (LCMV). This pseudotype was stable during ultracentrifugation and infected several cell lines from different species. Moreover, LCMV glycoproteins were not cell toxic.
摘要
假型化可以提高逆转录病毒载体的稳定性和转导效率。在此，我们描述了一种用淋巴细胞性脉络丛脑膜炎病毒（LCMV）包装的新型鼠白血病病毒假型。这种假型在超速离心过程中稳定，并且能感染来自不同物种的多种细胞系。此外，LCMV糖蛋白没有细胞毒性。
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