人宫颈干细胞条件培养液对卵巢癌异种移植瘤模型的影响。
Effects of Conditioned Medium from Human Uterine Cervical Stem Cells in an Ovarian Cancer Xenograft Mouse Model.
机构信息
Department of Physiology-Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.
出版信息
Cancer Genomics Proteomics. 2022 Sep-Oct;19(5):570-575. doi: 10.21873/cgp.20341.
BACKGROUND/AIM: Ovarian cancer is the most lethal of all gynecological cancers, despite advances in surgical techniques and medical treatments. During the last years, therapies based on mesenchymal stem cells and particularly their secretome (conditioned medium, CM) have emerged as promising treatments for various types of tumors.
MATERIALS AND METHODS
In the present study, we evaluated the in vivo antitumor effect of human uterine cervical stem cell conditioned medium (hUCESC-CM) after intraperitoneal administration in an ovarian cancer mouse model.
RESULTS
We found that intraperitoneal injection of hUCESC-CM in immunodeficient mice, injected fifty days previously with the human ovarian adenocarcinoma SKOV-3 cell line, significantly reduced abdominal tumor growth, and significantly increased overall survival, compared to control mice.
CONCLUSION
hUCESC-CM could be an alternative approach to intraperitoneal treatment of ovarian cancer, either administered alone and/or with conventional chemotherapy.
背景/目的：尽管在手术技术和医疗方面取得了进步，但卵巢癌仍是所有妇科癌症中最致命的一种。在过去的几年中，基于间充质干细胞的疗法，特别是它们的分泌组（条件培养基，CM），已成为治疗各种类型肿瘤的有前途的方法。
材料和方法
在本研究中，我们评估了人子宫颈干细胞条件培养基（hUCESC-CM）在卵巢癌小鼠模型中腹腔给药后的体内抗肿瘤作用。
结果
我们发现，与对照组小鼠相比，将 hUCESC-CM 腹腔注射到五十天前注入人卵巢腺癌 SKOV-3 细胞系的免疫缺陷小鼠中，可显著减少腹部肿瘤生长，并显著提高总生存率。
结论
hUCESC-CM 可作为一种替代方法，用于治疗卵巢癌的腹腔内治疗，可单独使用和/或与常规化疗联合使用。
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