Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Seoul, South Korea.
Gynecologic Cancer Branch & Center for Uterine Cancer, National Cancer Center, Goyang, South Korea.
BMC Cancer. 2018 May 29;18(1):601. doi: 10.1186/s12885-018-4498-z.
The survival of patients with ovarian cancer has improved because of surgery and chemotherapy. This study aimed to estimate the changes in survival rates among Korean women with ovarian cancer prior to the introduction of targeted therapy for ovarian cancer.
Data were obtained from the Korea Central Cancer Registry regarding patients who were diagnosed with epithelial ovarian cancer between 1995 and 2014. The relative survival rates were calculated for 5-year periods using the Ederer II method. Cox proportional hazard models were created to assess the associations of demographic and clinicopathological factors with ovarian cancer survival.
During the study period, 22,880 women were diagnosed with epithelial ovarian cancer. The 5-year relative survival rate improved from 57.2% during 1995-1999 to 63.8% during 2010-2014 (P < 0.001). Survival outcomes improved between 1995 and 1999 and 2010-2014 for the serous and endometrioid carcinoma subtypes (P < 0.001). However, no improvements were observed for the mucinous and clear cell carcinoma subtypes (P = 0.189 and P = 0.293, respectively). Multivariate analysis revealed that younger age, early stage, recent diagnosis, primary surgical treatment, and non-serous histological subtype were favorable prognostic factors.
Survival outcomes have improved for serous and endometrioid epithelial ovarian cancer in the last 20 years. However, no improvement was observed for patients with mucinous and clear cell carcinoma subtypes.
由于手术和化疗的发展，卵巢癌患者的生存率得到了提高。本研究旨在评估在引入卵巢癌靶向治疗之前，韩国女性卵巢癌患者的生存率变化情况。
从韩国中央癌症登记处获取了 1995 年至 2014 年间被诊断患有上皮性卵巢癌的患者数据。使用 Ederer II 法计算了 5 年期间的相对生存率。采用 Cox 比例风险模型评估了人口统计学和临床病理因素与卵巢癌生存的关系。
在研究期间，共有 22880 名女性被诊断为上皮性卵巢癌。5 年相对生存率从 1995-1999 年的 57.2%提高到 2010-2014 年的 63.8%（P<0.001）。1995 年至 1999 年和 2010 年至 2014 年期间，浆液性和子宫内膜样癌亚型的生存结局有所改善（P<0.001）。然而，黏液性和透明细胞癌亚型没有改善（P=0.189 和 P=0.293）。多变量分析显示，年龄较小、早期、近期诊断、初次手术治疗和非浆液性组织学亚型是有利的预后因素。
在过去的 20 年中，浆液性和子宫内膜样上皮性卵巢癌的生存结局有所改善。然而，黏液性和透明细胞癌亚型的患者没有改善。
