Bostrom B, Mirkin B L
J Clin Oncol. 1987 Jul;5(7):1090-7. doi: 10.1200/JCO.1987.5.7.1090.
The concentrations of homovanillic acid (HVA), hydroxymethoxyphenylethyleneglycol (HMPG), and vanillylmandelic acid (VMA) were determined in lumbar cerebrospinal fluid (CSF) specimens. The study population consisted of the following groups: control subjects with malignancies of nonneuroectodermal origin (mostly leukemia in remission), neuroblastoma (extracranial and intracranial or cranial metastases), brain tumors (neuroectodermal and glial), and retinoblastoma. A significant increase in the CSF concentration of HVA was observed in patients with brain tumors (neuroectodermal), neuroblastoma (intracranial or cranial metastases), and retinoblastoma when compared with age-matched controls. In contrast, HMPG and VMA concentrations did not differ from controls except in patients with neuroblastoma (intracranial or cranial metastases) and brain tumors (neuroectodermal) who had significant elevations in HMPG and VMA, respectively. An inverse correlation was noted between the CSF concentration of HVA and clinical response to therapy. Nonresponding patients exhibited increases in HVA when compared with pretreatment values. These data suggest that the quantitative determination of catecholamine metabolites in lumbar CSF is an effective method for diagnosing intracranial tumors of neuroectodermal origin and assessing their response to therapy.
在腰椎脑脊液（CSF）样本中测定了高香草酸（HVA）、羟甲氧基苯乙二醇（HMPG）和香草扁桃酸（VMA）的浓度。研究人群包括以下几组：非神经外胚层起源恶性肿瘤的对照受试者（大多为缓解期白血病）、神经母细胞瘤（颅外、颅内或颅转移）、脑肿瘤（神经外胚层和神经胶质）以及视网膜母细胞瘤。与年龄匹配的对照组相比，在患有脑肿瘤（神经外胚层）、神经母细胞瘤（颅内或颅转移）和视网膜母细胞瘤的患者中观察到脑脊液中HVA浓度显著升高。相比之下，除了神经母细胞瘤（颅内或颅转移）和脑肿瘤（神经外胚层）患者的HMPG和VMA分别显著升高外，HMPG和VMA浓度与对照组无差异。观察到脑脊液中HVA浓度与治疗的临床反应呈负相关。与治疗前值相比，无反应患者的HVA升高。这些数据表明，定量测定腰椎脑脊液中的儿茶酚胺代谢物是诊断神经外胚层起源的颅内肿瘤及其对治疗反应的有效方法。
