人脑脊液中单胺代谢物的浓度梯度
Concentration gradients of monoamine metabolites in human cerebrospinal fluid.
作者信息
Sjöström R, Ekstedt J, Anggård E
出版信息
J Neurol Neurosurg Psychiatry. 1975 Jul;38(7):666-8. doi: 10.1136/jnnp.38.7.666.
Abstract
The monamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), vanillylmandelic acid (VMA), and 4-hydroxy-3-methoxyphenylglycol (HMPG) were analysed in CSF from different regions of the CSF system to study the caudocranial concentration gradient of the metabolites. Four consecutive 10 ml fractions of CSF were withdrawn in 17 patients during the course of four minutes. The CSF pressure was monitored through a lumbar cannula because of suspected adult hydrocephalus. A pronounced gradient of the HVA concentration was found with a ratio between the last and the first fraction of 1,7. 5-HIAA showed a slight increase while HMPG and VMA showed no increase at higher levels of the CSF system. The results suggest that lumbar HVA reflects dopaminergic activity in the brain, whereas lumbar 5-HIAA and HMPG/VMA reflect the activity of 5-hydroxytryptamine and noradrenaline secreting neurones in both the brain and the spinal cord.
摘要
分析了脑脊液（CSF）系统不同区域脑脊液中的单胺代谢产物5-羟吲哚乙酸（5-HIAA）、高香草酸（HVA）、香草扁桃酸（VMA）和4-羟基-3-甲氧基苯乙二醇（HMPG），以研究这些代谢产物的尾颅浓度梯度。在4分钟内，从17例患者中连续抽取4个10 ml的脑脊液样本。由于怀疑成人脑积水，通过腰椎插管监测脑脊液压力。发现HVA浓度存在明显梯度，最后一份与第一份的比值为1.7。5-HIAA略有增加，而在脑脊液系统较高水平时，HMPG和VMA没有增加。结果表明，腰椎HVA反映大脑中的多巴胺能活性，而腰椎5-HIAA和HMPG/VMA反映大脑和脊髓中5-羟色胺和去甲肾上腺素分泌神经元的活性。
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本文引用的文献
1
Casts of the cerebral ventricles.脑室铸型
Br J Surg. 1953 May;40(164):525-43. doi: 10.1002/bjs.18004016403.
2
5-hydroxyindoleacetic and homovanillic acid levels in the cerebrospinal fluid of healthy volunteers and patients with Parkinson's syndrome.健康志愿者和帕金森综合征患者脑脊液中5-羟吲哚乙酸和高香草酸水平
Life Sci. 1967 Jul 1;6(13):1449-54. doi: 10.1016/0024-3205(67)90193-2.
3
Concentrations of 5-hydroxyindolylacetic acid and homovanillic acid in the cerebrospinal fluid of the dog before and during treatment with probenecid.丙磺舒治疗前及治疗期间犬脑脊液中5-羟吲哚乙酸和高香草酸的浓度。
Life Sci. 1966 Sep;5(17):1571-5. doi: 10.1016/0024-3205(66)91026-5.
4
Origin of 5-hydroxyindoleacetic acid in the spinl fluid.脊髓液中5-羟吲哚乙酸的来源。
Science. 1971 Aug 20;173(3998):738-40. doi: 10.1126/science.173.3998.738.
5
Cerebral metabolites in cerebrospinal fluid as a biochemical approach to the brain.脑脊液中的脑代谢物作为研究大脑的生化方法。
Brain. 1970;93(2):357-68. doi: 10.1093/brain/93.2.357.
6
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Life Sci. 1973 Dec 16;13(12):1655-64. doi: 10.1016/0024-3205(73)90113-6.
7
On the origin of homovanillic acid (HVA) in the cerebrospinal fluid.关于脑脊液中高香草酸（HVA）的起源
J Neural Transm. 1973;34(2):153-7. doi: 10.1007/BF01244668.
8
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9
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Eur J Clin Pharmacol. 1972 Jun;4(3):170-6. doi: 10.1007/BF00561141.
10
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Life Sci I. 1971 Apr 1;10(7):405-14. doi: 10.1016/0024-3205(71)90146-9.
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