RAK College of Dental Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE.
Department of Oral Medicine and Radiology, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Center, Hyderabad, Telangana, India.
J Contemp Dent Pract. 2022 May 1;23(5):552-557.
The present study aimed at evaluating the efficacy of spirulina 500 mg in reducing the burning sensation and lesion size in oral lichen planus (OLP).
A total of 60 subjects who attended the oral medicine specialty clinic with histopathologically confirmed OLP and having symptoms of burning sensation were recruited for the study. They were randomly divided into two groups: group A (30) subjects were prescribed Spirulina 500 mg twice daily along with only a week application of topical triamcinolone acetonide 0.1% thrice daily; group B subjects were prescribed topical triamcinolone acetonide 0.1% alone thrice daily for 8 weeks. Both the groups were followed up posttreatment monthly for three consecutive months.
Data were recorded, and statistical analysis by using ANOVA one-way test, and Chi-square test were performed, which showed statistically significant -value (<0.005) for the parameters "burning sensation" and "size of the lesion". When compared between groups, group A showed a favorable outcome of the intervention.
Spirulina 500 mg supplementation twice daily could be effective adjunct therapy with steroids to treat OLP.
This research allowed us to delve into spirulina as one of the treatment modalities for OLP. Further studies are needed as it is a rich source of proteins and vitamins and demonstrates potent anti-inflammatory, immunomodulatory, and antioxidant actions.
本研究旨在评估螺旋藻 500mg 减轻口腔扁平苔藓（OLP）烧灼感和病变面积的疗效。
共招募了 60 名在口腔医学专科诊所就诊的组织病理学确诊为 OLP 且有烧灼感症状的患者参与本研究。他们被随机分为两组：A 组（30 名）患者每天服用两次螺旋藻 500mg，并同时每天使用曲安奈德醋酸酯 0.1%外用三次，共一周；B 组患者每天外用曲安奈德醋酸酯 0.1%三次，共 8 周。两组患者在治疗后每月随访三个月。
记录数据，并进行方差分析单因素检验和卡方检验，“烧灼感”和“病变大小”这两个参数均显示出统计学意义（<0.005）。当组间比较时，A 组显示出干预的良好效果。
每天两次补充螺旋藻 500mg 可能是类固醇治疗 OLP 的有效辅助疗法。
这项研究使我们能够深入研究螺旋藻作为 OLP 的一种治疗方法。需要进一步研究，因为它是蛋白质和维生素的丰富来源，具有强大的抗炎、免疫调节和抗氧化作用。
