Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Appl Radiat Isot. 2022 Oct;188:110405. doi: 10.1016/j.apradiso.2022.110405. Epub 2022 Aug 14.
Y bremsstrahlung Single-Photon Emission Tomography (SPECT) imaging is employed to check the possibility of extrahepatic uptake and the quantification of delivered dose in Transarterial Radioembolization (TARE). Y bremsstrahlung SPECT imaging is challenging due to the nature of bremsstrahlung photons. We reported a Monte Carlo study using the resin microspheres loaded with Y and Nanoparticles (NPs) in the TARE. By injection of Bismuth (Bi) and Europium (Eu) NPs into the resin microspheres, the sensitivity and the contrast to noise ratio increased for the bremsstrahlung planar images. The highest signal to background ratio was observed in the characteristic X-ray planar images taken with the energy window at the Kα ± 10 keV when Eu NPs were incorporated into the microsphere. The dose enhancement ratio decreased dramatically at NP concentrations >2.4 M. Incorporating NPs into the resin microspheres improves the quality of post-treatment images and establishes a standardized imaging protocol for post-treatment imaging by characteristic X-rays.
Y 韧致辐射单光子发射断层扫描（SPECT）成像用于检查经肝动脉放射栓塞术（TARE）中肝外摄取的可能性和所给予剂量的定量。由于韧致辐射光子的性质，Y 韧致辐射 SPECT 成像具有挑战性。我们报告了一项使用负载 Y 的树脂微球和 TARE 中纳米颗粒（NPs）的蒙特卡罗研究。通过将铋（Bi）和铕（Eu）NPs 注入树脂微球中，韧致辐射平面图像的灵敏度和对比噪声比增加。当将 Eu NPs 掺入微球时，在能量窗口为 Kα ± 10 keV 时获得的特征 X 射线平面图像中观察到最高的信号与背景比。当 NP 浓度>2.4 M 时，剂量增强比急剧下降。将 NPs 掺入树脂微球中可改善治疗后图像的质量，并通过特征 X 射线建立用于治疗后成像的标准化成像方案。
