Zhang Ling, Shao Ji, Tan Si-Wei, Ye Hai-Peng, Shan Xiao-Yue
Department of Sanitation Test, Hangzhou Hospital for the Prevention and Treatment of Occupational Disease, Hangzhou, PR China.
Department of Sanitation Test, Hangzhou Hospital for the Prevention and Treatment of Occupational Disease, Hangzhou, PR China.
J Trace Elem Med Biol. 2022 Dec;74:127061. doi: 10.1016/j.jtemb.2022.127061. Epub 2022 Aug 12.
Numerous studies have investigated the relationship between serum copper/zinc ratio and lung cancer. However, the results are inconsistent. Therefore, we evaluated the association between copper/zinc ratio and lung cancer.
Observational studies reporting serum copper/zinc ratio in lung cancer patients and controls were identified from PubMed, Web of Science, EMBASE, CNKI and Wanfang databases online before December 2021. Summary standard mean difference (SMD) and the corresponding 95 % confidence interval (95 % CI) were applied to compare the serum serum copper/zinc ratio between lung cancer patients and controls using a random-effects model.
Thirty-nine articles including 3598 lung cancer patients, 1402 benign lung diseases, and 3314 healthy controls were included in this study. The pooled results showed that the lung cancer patients had significantly higher serum copper/zinc ratio than healthy controls [SMD (95 % CI): 1.62 (1.31, 1.93)] and patients with benign lung diseases [SMD (95 % CI): 0.60 (0.36, 0.84)]. The results were robust according to sensitivity analysis. Meanwhile, consistent results were obtained both in European populations and Asian populations. Moreover, serum copper/zinc ratio was significant higher in patients with advanced stage of lung cancer than that in patients with early stage of lung cancer.
The results showed that elevated serum copper/zinc ratio might be associated with increased risk of lung cancer.
众多研究探讨了血清铜/锌比值与肺癌之间的关系。然而，结果并不一致。因此，我们评估了铜/锌比值与肺癌之间的关联。
通过检索PubMed、Web of Science、EMBASE、中国知网和万方数据库，筛选出2021年12月之前在线发表的关于肺癌患者和对照组血清铜/锌比值的观察性研究。采用随机效应模型，应用汇总标准均数差（SMD）及相应的95%置信区间（95%CI）比较肺癌患者与对照组之间的血清铜/锌比值。
本研究纳入了39篇文章，包括3598例肺癌患者、1402例良性肺部疾病患者和3314例健康对照。汇总结果显示，肺癌患者的血清铜/锌比值显著高于健康对照[SMD（95%CI）：1.62（1.31，1.93）]和良性肺部疾病患者[SMD（95%CI）：0.60（0.36，0.84）]。敏感性分析结果显示该结果具有稳健性。同时，在欧洲人群和亚洲人群中均得到了一致的结果。此外，肺癌晚期患者的血清铜/锌比值显著高于早期患者。
结果表明，血清铜/锌比值升高可能与肺癌风险增加有关。
