Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany.
Institute for Research in Operative Medicine (IFOM), Witten/Herdecke University, Ostmerheimer Str. 200, 51109, Cologne, Germany; Institute for Medical Statistics, University Medical Center Göttingen, Germany.
J Clin Epidemiol. 2022 Nov;151:104-112. doi: 10.1016/j.jclinepi.2022.08.004. Epub 2022 Aug 17.
To investigate reporting and methodological characteristics of overviews on adverse (drug-associated) events (AEs) of pharmacological interventions.
We searched MEDLINE, Embase, Epistemonikos, and the Cochrane Database of Systematic Reviews from inception to May 17, 2021 for overviews exclusively investigating AEs of pharmacological interventions. We extracted general, reporting, and methodological characteristics and analyzed data descriptively.
We included 27 overviews, 70% of which were published in 2016 or later. The most common nomenclature in the title was "overview" (56%), followed by "umbrella review" (26%). The median number of included systematic reviews (SRs) in each overview was 15 (interquartile range 7-34). Study selection methods were reported in 52%, methods for data extraction in 67%, and methods for critical appraisal in 63% of overviews. An assessment of methodological quality of included SRs was performed in 70% of overviews. Only 22% of overviews reported strategies for dealing with overlapping SRs. An assessment of the certainty of the evidence was performed in 33% of overviews.
To ensure methodological rigor, authors of overviews on AEs should follow available guidance for the conduct and reporting of overviews.
调查药物相关不良事件（AE）的药理学干预综合报告的报告和方法学特征。
我们检索了 MEDLINE、Embase、Epistemonikos 和 Cochrane 系统评价数据库，从建库到 2021 年 5 月 17 日，专门检索药理学干预药物不良事件的综合报告。我们提取了一般、报告和方法学特征，并进行了描述性数据分析。
我们纳入了 27 篇综述，其中 70%的综述发表于 2016 年或之后。标题中最常见的命名法是“综述”（56%），其次是“伞状综述”（26%）。每篇综述纳入的系统评价（SR）中位数为 15 项（四分位距 7-34）。52%的综述报告了研究选择方法，67%的综述报告了数据提取方法，63%的综述报告了关键评估方法。70%的综述对纳入的 SR 进行了方法学质量评估。只有 22%的综述报告了处理重叠 SR 的策略。33%的综述对证据的确定性进行了评估。
为了确保方法学严谨性，AE 综合报告的作者应遵循现有的综合报告指南。
