School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, Shanghai Key Laboratory of Multidimensional Information Processing, Engineering Research Centre for Nanophotonics and Advanced Instrument (Ministry of Education), East China Normal University, Shanghai, 200241, China.
Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, Haifa, 320003, Israel.
Adv Sci (Weinh). 2022 Oct;9(29):e2202635. doi: 10.1002/advs.202202635. Epub 2022 Aug 21.
Herein, a multifunctional bilayer wound patch is developed by integrating a debonding-on-demand polymeric tissue adhesive (DDPTA) with an ionic conducting elastomer (ICE). As a skin adhesive layer, the DDPTA is soft and adherent at skin temperature but hard and non-tacky when cooled, so it provides unique temperature-triggered quick adhesion and non-forced detachment from the skin. During use, the dense surface of the DDPTA prevents blood infiltration and reduces unnecessary blood loss with gentle pressing. Moreover, its hydrophobic matrix helps to repel blood and prevents the formation of clots, thus precluding wound tearing during its removal. This unique feature enables the DDPTA to avoid the severe deficiencies of hydrophilic adhesives, providing a reliable solution for a wide range of secondary wound injuries. The DDPTA is versatile in that it can be covered with ICE to configure a DDPTA@ICE patch for initiating non-verbal communication systems by the fingers, leading toward sign language recognition and a remote clinical alarm system. This multifunctional wound patch with debonding-on-demand can promote a new style of tissue sealant for convenient clinical communication.
本文通过将一种按需离型的聚合物组织粘合剂 (DDPTA) 与离子导电弹性体 (ICE) 集成，开发了一种多功能双层伤口贴片。作为一种皮肤粘合剂层，DDPTA 在皮肤温度下柔软且具有粘性，但冷却时则变得坚硬且无粘性，因此提供了独特的温度触发快速粘附和非强制从皮肤分离的特性。在使用过程中，DDPTA 的密集表面可以防止血液渗透，并通过轻轻按压减少不必要的失血。此外，其疏水基质有助于排斥血液并防止形成血栓，从而避免在移除时伤口撕裂。这种独特的特性使 DDPTA 能够避免亲水型粘合剂的严重缺陷，为各种继发性伤口损伤提供了可靠的解决方案。DDPTA 用途广泛，它可以用 ICE 覆盖以配置 DDPTA@ICE 贴片，从而通过手指启动非语言通信系统，实现手语识别和远程临床报警系统。这种具有按需离型功能的多功能伤口贴片可以促进一种新型的组织密封剂，方便临床沟通。
