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附加内固定融合术在胸段黄韧带骨化症治疗中的价值

Value of Additional Instrumented Fusion in the Treatment of Thoracic Ossification of the Ligamentum Flavum.

作者信息

Hwang Sung Hwan, Chung Chun Kee, Kim Chi Heon, Yang Seung Heon, Choi Yunhee, Yoon Joonho

机构信息

Department of Neurosurgery, The Armed Forces Capital Hospital of Korea, Seongnam, Korea.

Human Brain Function Laboratory, Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.

出版信息

J Korean Neurosurg Soc. 2022 Sep;65(5):719-729. doi: 10.3340/jkns.2021.0167. Epub 2022 Aug 22.

Abstract

OBJECTIVE

The ossification of the ligamentum flavum (OLF) is one of the major causes of thoracic myelopathy. Surgical decompression with or without instrumented fusion is the mainstay of treatment. However, few studies have reported on the added effect of instrumented fusion. The objective of this study was to compare clinical and radiological outcomes between surgical decompression without instrumented fusion (D-group) and that with instrumented fusion (F-group).

METHODS

A retrospective review was performed on 28 patients (D-group, n=17; F-group, n=11) with thoracic myelopathy due to OLF. The clinical parameters compared included scores of the Japanese Orthopedic Association (JOA), the Visual analogue scale of the back and leg (VAS-B and VAS-L), and the Korean version of the Oswestry disability index (K-ODI). Radiological parameters included the sagittal vertical axis (SVA), the pelvic tilt (PT), the sacral slope (SS), the thoracic kyphosis angle (TKA), the segmental kyphosis angle (SKA) at the operated level, and the lumbar lordosis angle (LLA; a negative value implying lordosis). These parameters were measured preoperatively, 1 year postoperatively, and 2 years postoperatively, and were compared with a linear mixed model.

RESULTS

After surgery, all clinical parameters were significantly improved in both groups, while VAS-L was more improved in the Fgroup than in the D-group (-3.4±2.5 vs. -1.3±2.2, p=0.008). Radiological outcomes were significantly different in terms of changes in TKA, SKA, and LLA. Changes in TKA, SKA, and LLA were 2.3°±4.7°, -0.1°±1.4°, and -1.3°±5.6° in the F-group, which were significantly lower than 6.8°±6.1°, 3.0°±2.8°, and 2.2°±5.3° in the D-group, respectively (p=0.013, p<0.0001, and p=0.037). Symptomatic recurrence of OLF occurred in one patient of the D-group at postoperative 24 months.

CONCLUSION

Clinical improvement was achieved after decompression surgery for OLF regardless of whether instrumented fusion was added. However, adding instrumented fusion resulted in better outcomes in terms of lessening the progression of local and regional kyphosis and improving leg pain. Decompression with instrumented fusion may be a better surgical option for thoracic OLF.

摘要

目的

黄韧带骨化(OLF)是胸段脊髓病的主要病因之一。手术减压加或不加内固定融合是主要的治疗方法。然而,很少有研究报道内固定融合的附加效果。本研究的目的是比较无内固定融合的手术减压组(D组)和有内固定融合的手术减压组(F组)的临床和影像学结果。

方法

对28例因OLF导致胸段脊髓病的患者进行回顾性研究(D组,n = 17;F组,n = 11)。比较的临床参数包括日本骨科协会(JOA)评分、背部和腿部视觉模拟量表(VAS-B和VAS-L)以及韩国版Oswestry功能障碍指数(K-ODI)。影像学参数包括矢状垂直轴(SVA)、骨盆倾斜度(PT)、骶骨倾斜度(SS)、胸椎后凸角(TKA)、手术节段的节段性后凸角(SKA)以及腰椎前凸角(LLA;负值表示前凸)。这些参数在术前、术后1年和术后2年进行测量,并采用线性混合模型进行比较。

结果

手术后,两组的所有临床参数均显著改善,而F组的VAS-L改善程度优于D组(-3.4±2.5对-1.3±2.2,p = 0.008)。在TKA、SKA和LLA的变化方面,影像学结果有显著差异。F组TKA、SKA和LLA的变化分别为2.3°±4.7°、-0.1°±1.4°和-1.3°±5.6°,显著低于D组的6.8°±6.1°、3.0°±2.8°和2.2°±5.3°(p = 0.013、p < 0.0001和p = 0.037)。D组有1例患者在术后24个月出现OLF症状复发。

结论

无论是否加用内固定融合,OLF减压手术后临床症状均有改善。然而,加用内固定融合在减轻局部和节段性后凸进展以及改善腿痛方面效果更好。内固定融合减压可能是胸段OLF更好的手术选择。

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