Translational Cardio-Renal Medicine, Saarland University, Homburg/Saar, Germany.
Department of Nephrology and Hypertension, Saarland University, Homburg/Saar, Germany.
Kidney Int. 2022 Sep;102(3):469-471. doi: 10.1016/j.kint.2022.05.016.
Activation of the Wnt/β-catenin pathway represents a hallmark in the development of kidney fibrosis. Herein, Chen et al. report that Klotho-derived peptide 6, a peptide mimicking the function of the protein Klotho, directly binds to endogenous Wnt ligands and, thereby, serves as a small-molecule inhibitor of canonical Wnt/β-catenin signaling. In diabetic kidney disease, Klotho-derived peptide 6 reduces glomerular injury and preserves kidney function, highlighting Klotho-derived peptide 6 as a novel therapeutic agent.
Wnt/β-catenin 通路的激活是肾脏纤维化发展的一个标志。在此，Chen 等人报告称，Klotho 衍生肽 6 是一种模拟蛋白 Klotho 功能的肽，可直接与内源性 Wnt 配体结合，从而成为经典 Wnt/β-catenin 信号的小分子抑制剂。在糖尿病肾病中，Klotho 衍生肽 6 可减少肾小球损伤并维持肾脏功能，凸显了 Klotho 衍生肽 6 作为一种新型治疗剂的潜力。
