GWAS 中的肾脏疾病进展和碰撞偏差。

Kidney disease progression and collider bias in GWAS.

机构信息

Division of Nephrology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.

出版信息

Kidney Int. 2022 Sep;102(3):476-478. doi: 10.1016/j.kint.2022.06.018.

DOI:10.1016/j.kint.2022.06.018

PMID:35988936

Abstract

New genome-wide meta-analysis for longitudinal kidney function decline identified several genetic loci related to kidney disease progression. The study illustrated the complexity of modeling longitudinal traits in genome-wide association studies and highlighted the issue of a collider bias that can be introduced when a kidney disease progression phenotype is adjusted for baseline kidney function. Herein, we briefly outline the key findings of this study, their limitations, and implications for future studies.

摘要

一项新的全基因组荟萃分析研究发现了与肾脏疾病进展相关的多个遗传位点，这些遗传位点与纵向肾功能下降有关。该研究说明了在全基因组关联研究中对纵向特征进行建模的复杂性，并强调了当肾脏疾病进展表型调整为基线肾功能时可能引入的碰撞偏差问题。在此，我们简要概述了这项研究的主要发现、其局限性以及对未来研究的意义。