低心肺适能是否为儿童和成人代谢综合征的特征？
Is low cardiorespiratory fitness a feature of metabolic syndrome in children and adults?
机构信息
Faculty of Sport and Health Sciences, University of Jyväskylä, Finland; Institute of Biomedicine, University of Eastern Finland, Finland.
Institute of Biomedicine, University of Eastern Finland, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, University of Eastern Finland, Finland.
出版信息
J Sci Med Sport. 2022 Nov;25(11):923-929. doi: 10.1016/j.jsams.2022.08.002. Epub 2022 Aug 4.
OBJECTIVES
Cardiorespiratory fitness has been inversely associated with risk of cardiometabolic diseases. However, there are no studies comparing the independent associations of cardiorespiratory fitness scaled by body size and composition using different approaches with cardiometabolic risk factors between children and adults. We therefore investigated these associations in children and adults using same measures for cardiorespiratory fitness and cardiometabolic risk factors.
DESIGN
Cross-sectional.
METHODS
A total of 352 children (47.2 % girls) and 572 men were included in the study. Peak oxygen uptake (V̇O) was measured during a maximal exercise test on a cycle ergometer and was scaled by total body mass, total fat free mass, and allometrically modelled body mass, fat free mass, and stature. Insulin, glucose, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were assessed from fasting blood samples and systolic blood pressure and diastolic blood pressure were measured. Homeostatic model assessment for insulin resistance and continuous metabolic risk score were computed.
RESULTS
V̇O scaled by body mass was inversely associated with insulin, homeostatic model assessment for insulin resistance, triglycerides, diastolic blood pressure, the cardiometabolic risk score and the number of cardiometabolic risk factors in children and adults. However, these associations attenuated remarkably when V̇O was scaled by total fat free mass or allometrically modelled body mass, fat free mass, or stature. V̇O was consistently and positively associated with high-density lipoprotein cholesterol in children and adults irrespective of the scaling approach.
CONCLUSIONS
The inverse associations of cardiorespiratory fitness with cardiometabolic risk factors among children and adults attenuated remarkably when body size and composition were appropriately controlled for. However, the positive association between cardiorespiratory fitness and high-density lipoprotein cholesterol was consistent irrespective of the scaling approach.
目的
心肺适能与心血管代谢疾病风险呈负相关。然而，目前尚无研究比较使用不同方法按身体大小和成分对心肺适能进行标化后与儿童和成人心血管代谢危险因素的独立关联。因此，我们使用相同的心肺适能和心血管代谢危险因素测量方法在儿童和成人中研究了这些关联。
设计
横断面研究。
方法
本研究共纳入 352 名儿童（47.2%为女性）和 572 名男性。在测功计上进行最大运动试验时测量峰值摄氧量（V̇O），并按总体质量、总去脂体重、以及按比例建模的总体质量、去脂体重和身高进行标化。胰岛素、葡萄糖、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇从空腹血样中评估，收缩压和舒张压从测量。计算胰岛素抵抗的稳态模型评估和连续代谢风险评分。
结果
按体重标化的 V̇O 与儿童和成人的胰岛素、胰岛素抵抗的稳态模型评估、甘油三酯、舒张压、心血管代谢风险评分和心血管代谢危险因素数量呈负相关。然而，当 V̇O 按总去脂体重或按比例建模的总体质量、去脂体重或身高进行标化时，这些关联显著减弱。无论采用何种标化方法，V̇O 与儿童和成人的高密度脂蛋白胆固醇均呈持续正相关。
结论
在适当控制身体大小和成分后，儿童和成人的心肺适能与心血管代谢危险因素之间的负相关显著减弱。然而，心肺适能与高密度脂蛋白胆固醇之间的正相关无论采用何种标化方法均一致。
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