Zandi Mohammad, Dehghan Arash, Najafi Amir, Kamyari Naser, Abbasi Soheil
Department of Oral and Maxillofacial Surgery, Hamadan University of Medical Sciences, Hamadan, Iran; Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran.
Br J Oral Maxillofac Surg. 2022 Oct;60(8):1068-1073. doi: 10.1016/j.bjoms.2022.02.005. Epub 2022 Feb 23.
This study was performed to evaluate the effect of teriparatide therapy on the healing of osteochondral defects of the mandibular condylar. Ninety-six rats underwent surgery to create a defect in the condylar head on one side of the mandible, and were divided into two groups. One group received subcutaneous injection of 2 µg/kg/day teriparatide, and the other group received normal saline until sacrifice. On postoperative days 20, 40, and 60, 16 animals from each group were sacrificed, and bone and cartilage healing was histologically evaluated and semiquantitatively scored (1-5). The mean difference in healing score of the cartilaginous and subchondral parts of the defect between the teriparatide and control groups at days 20, 40 and 60 were 0.438 and 0.438, 0.813 and 0.750, and 1.125 and 0.813, respectively. The healing scores of the osteochondral defects in the teriparatide group were significantly (p< 0.05) higher than that in the control group at days 40 and 60. This study has shown beneficial effects of teriparatide on the healing of condylar osteochondral defects in rats. Clinical trials are required to extrapolate these findings to humans.
本研究旨在评估特立帕肽治疗对下颌髁突骨软骨缺损愈合的影响。96只大鼠接受手术，在下颌骨一侧的髁突头部制造缺损，并分为两组。一组皮下注射2μg/kg/天的特立帕肽，另一组注射生理盐水直至处死。在术后第20、40和60天，每组处死16只动物，对骨和软骨愈合进行组织学评估并进行半定量评分（1 - 5分）。在第20、40和60天时，特立帕肽组与对照组缺损软骨和软骨下部分愈合评分的平均差异分别为0.438和0.438、0.813和0.750、1.125和0.813。在第40天和60天时，特立帕肽组骨软骨缺损的愈合评分显著高于对照组（p < 0.05）。本研究表明特立帕肽对大鼠髁突骨软骨缺损的愈合有有益作用。需要进行临床试验以将这些发现推广到人类。
