Bali Anoushka, Dang Ashujot Kaur, Gonzalez Daniel A, Kumar Rajeswar, Asif Saba
Research, Acharya Shri Chander College of Medical Sciences & Hospital, Jammu, IND.
Research, Government Medical College Patiala, Patiala, IND.
Cureus. 2022 Jul 20;14(7):e27065. doi: 10.7759/cureus.27065. eCollection 2022 Jul.
Ketamine is a phencyclidine derivative that acts as a noncompetitive N-methyl-D-aspartate as well as a glutamate receptor antagonist. It also has other minor mechanisms that contribute to its extensive drug profile. Ketamine is a bronchodilator and maintains normal airway reflexes and, thus, permits spontaneous respiration. This, coupled with the fact that it produces potent analgesia, makes it highly suitable for children. Despite its many merits, the drug's side effects, along with its cultural image of being a drug of abuse, a drug used in veterinary medicine, or a "date-rape drug" have sullied its reputation within the armamentarium of medicine. Even though it is widely used in developing countries, its use in Western nations has diminished. We have strived to explore the various clinical uses of ketamine in children through this article. In addition, the article also highlights how some of the fears associated with using the drug are unfounded and provides ways by which the drug's side effects can be prevented and managed.
氯胺酮是一种苯环己哌啶衍生物，它作为一种非竞争性N-甲基-D-天冬氨酸以及谷氨酸受体拮抗剂发挥作用。它还有其他一些次要机制，这促成了其广泛的药物特性。氯胺酮是一种支气管扩张剂，可维持正常气道反射，因此允许自主呼吸。这一点，再加上它能产生强效镇痛作用，使其非常适合儿童使用。尽管氯胺酮有诸多优点，但该药物的副作用，以及它作为滥用药物、兽用药物或“约会强奸药物”的文化形象，损害了它在药物库中的声誉。尽管它在发展中国家被广泛使用，但在西方国家其使用量已经减少。我们通过本文努力探索氯胺酮在儿童中的各种临床用途。此外，本文还强调了一些与使用该药物相关的担忧是毫无根据的，并提供了预防和管理该药物副作用的方法。
