112例老年晚期非小细胞肺癌患者的预后因素

Prognostic factors of 112 elderly patients with advanced non-small cell lung cancer.

作者信息

Ran Fanglan, Liu Qin

机构信息

Fanglan Ran, Department of Respiratory and Critical Care Medicine, Chongqing University Fuling Hospital, 2 Gaosuntang Road, Chongqing 408000, P.R. China.

Qin Liu, Department of Respiratory and Critical Care Medicine, Chongqing University Fuling Hospital, 2 Gaosuntang Road, Chongqing 408000, P.R. China.

出版信息

Pak J Med Sci. 2022 Jul-Aug;38(6):1674-1679. doi: 10.12669/pjms.38.6.5457.

DOI:10.12669/pjms.38.6.5457

PMID:35991233

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9378386/

Abstract

OBJECTIVES

In this study we retrospectively analyzed the prognostic factors of patients with advanced non-small cell lung cancer (NSCLC).

METHODS

Clinical data of 112 patients with advanced NSCLC treated in the tumor center of our hospital from January 2016 to December 2017 were analyzed retrospectively, follow up the survival of patients, the effects of gender, age, tumor stage, pathological type, performance status (PS) score, smoking history and treatment on the survival of elderly patients with advanced NSCLC were analyzed. The median survival time was 12.0 months, and the median age was 74 years. The 3-year survival rate after confirmation of advanced lung cancer was 6.25%. Kaplan Meier univariate analysis showed that age, PS score, smoking status and treatment correlated with the prognosis(<0.05). Cox multivariate analysis showed that age >70 years, PS score>2, smoking and no targeted therapy were independent adverse prognostic factors for elderly patients with advanced NSCLC(<0.05).

CONCLUSIONS

Age, PS score, smoking and treatment mode affect the prognosis and survival of elderly patients with advanced NSCLC. Effective treatment should be given according to the principle of evidence-based medicine.

摘要

目的

本研究回顾性分析晚期非小细胞肺癌（NSCLC）患者的预后因素。

方法

回顾性分析2016年1月至2017年12月在我院肿瘤中心接受治疗的112例晚期NSCLC患者的临床资料，随访患者生存情况，分析性别、年龄、肿瘤分期、病理类型、体能状态（PS）评分、吸烟史及治疗对老年晚期NSCLC患者生存的影响。中位生存时间为12.0个月，中位年龄为74岁。确诊为晚期肺癌后的3年生存率为6.25%。Kaplan Meier单因素分析显示年龄、PS评分、吸烟状态及治疗与预后相关（P<0.05）。Cox多因素分析显示年龄>70岁、PS评分>2、吸烟及未行靶向治疗是老年晚期NSCLC患者独立的不良预后因素（P<0.05）。