Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Department of Medical Oncology and Hematology, University of Lübeck, Lübeck, Germany.
Anticancer Res. 2020 Mar;40(3):1665-1668. doi: 10.21873/anticanres.14117.
BACKGROUND/AIM: Treatment of elderly patients with cancer has increasing importance. Since many of these patients may not tolerate standard treatments, they might benefit from personalized approaches. This study was performed to identify characteristics that allow estimation of survival in elderly patients with prostate cancer with cerebral metastases.
Data of 21 elderly patients (≥65 years) receiving whole-brain radiotherapy (WBRT) for cerebral metastases from prostate cancer were retrospectively evaluated. Six characteristics were investigated: WBRT program, age, Karnofsky performance score (KPS), number of brain metastases, extra-cerebral metastases, and interval between diagnosis of prostate cancer and WBRT.
On univariate analyses, KPS ≥80% resulted in better survival than KPS ≤70% (log-rank p=0.018). Three-month survival was 60% vs. 36%, and 6-month survival 50% vs. 0%, respectively. In the Cox model, KPS maintained significance (hazard ratio=3.18, p=0.031).
KPS is a significant prognostic factor of survival in elderly patients with prostate cancer receiving WBRT for cerebral metastases.
背景/目的：治疗老年癌症患者的重要性日益增加。由于这些患者中的许多人可能无法耐受标准治疗，因此他们可能受益于个性化的方法。本研究旨在确定特征，以估计患有脑转移的老年前列腺癌患者的生存情况。
回顾性评估了 21 名接受全脑放疗（WBRT）治疗前列腺癌脑转移的老年患者（≥65 岁）的数据。研究了 6 个特征：WBRT 方案、年龄、卡氏功能状态评分（KPS）、脑转移灶数量、颅外转移灶和前列腺癌诊断与 WBRT 之间的间隔。
单因素分析显示，KPS≥80%的患者的生存情况优于 KPS≤70%的患者（对数秩检验，p=0.018）。3 个月生存率分别为 60%和 36%，6 个月生存率分别为 50%和 0%。在 Cox 模型中，KPS 仍然具有显著意义（风险比=3.18，p=0.031）。
KPS 是接受 WBRT 治疗脑转移的老年前列腺癌患者生存的重要预后因素。
