Department of Gastroenterology, The First Hospital of Yulin Shanxi, Yulin City, Shanxi Province, P. R. China.
Scand J Gastroenterol. 2022 Nov;57(11):1344-1348. doi: 10.1080/00365521.2022.2088246. Epub 2022 Aug 20.
Gastric cancer (GC) causes no symptoms at early stages. However, with the progression, GC causes symptoms mimicking normal gastrointestinal issues, such as irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), gastritis, or peptic ulcers (PU). CircRNA circSOBP has been characterized as a critical regulator in prostate cancer. The present study aimed to study its involvement in GC.
Plasma samples were collected from GC patients ( = 64), IBS patients ( = 64), GERD patients ( = 64), gastritis patients ( = 64), PU patients ( = 64), and healthy controls (HCs, = 64). Paired GC and non-tumor samples were from all GC patients ( = 64). Tissue and plasma samples were subjected to RT-qPCR to determine circSOBP expression. The role of circSOBP in distinguishing GC patients from other patients was analyzed by ROC curve. The 64 patients were followed up for 5 years to study the role of circSOBP in predicting the survival of GC patients.
Decreased circSOBP RNA accumulation was observed in GC tissues compared to normal tissue samples. Decreased plasma circSOBP accumulation was only observed in GC patients, but not other patients, compared to HCs. With plasma circSOBP as a biomarker, GC patients were separated from other patients and HCs. Patients with high plasma or tissue levels of circSOBP showed better survival conditions. In addition, plasma and tissue circSOBP levels were only closely correlated with GC patients' tumor metastasis, but not other clinical factors.
Decreased circSOBP accumulation may be applied in clinical practice to improve the diagnosis and prognosis of GC.
胃癌（GC）在早期阶段没有症状。然而，随着病情的发展，GC 会引起类似于正常胃肠道问题的症状，如肠易激综合征（IBS）、胃食管反流病（GERD）、胃炎或消化性溃疡（PU）。环状 RNA circSOBP 已被证实为前列腺癌的关键调节因子。本研究旨在研究其在 GC 中的参与。
收集了 64 例 GC 患者、64 例 IBS 患者、64 例 GERD 患者、64 例胃炎患者、64 例 PU 患者和 64 例健康对照者（HCs）的血浆样本。所有 GC 患者（n=64）均采集配对的 GC 组织和非肿瘤组织样本。通过 RT-qPCR 检测 circSOBP 的表达。通过 ROC 曲线分析 circSOBP 在区分 GC 患者与其他患者中的作用。对 64 例患者进行了 5 年的随访，以研究 circSOBP 在预测 GC 患者生存中的作用。
与正常组织样本相比，GC 组织中 circSOBP RNA 的积累减少。与 HCs 相比，仅在 GC 患者中观察到血浆 circSOBP 积累减少，而在其他患者中未观察到。以血浆 circSOBP 为生物标志物，GC 患者与其他患者和 HCs 分离。血浆或组织中 circSOBP 水平高的患者生存条件更好。此外，血浆和组织 circSOBP 水平仅与 GC 患者的肿瘤转移密切相关，而与其他临床因素无关。
circSOBP 积累减少可能应用于临床实践，以改善 GC 的诊断和预后。
