Liu Ao-Ran, Yan Zi-Wei, Jiang Li-Yue, Lv Zhi, Li Yan-Ke, Wang Ben-Gang
Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Education Department, Shenyang, China.
Tangdu Hospital of the Fourth Military Medical University, Xi'an, China.
Front Med (Lausanne). 2022 Oct 13;9:1009021. doi: 10.3389/fmed.2022.1009021. eCollection 2022.
() is one of the globally recognized causative factors of gastric cancer (GC). Currently, no definite therapy and drugs for -related GC have been widely acknowledged although infection could be eradicated in early stage. Inflammation and immune response are spontaneous essential stages during infection. may mediate immune escape by affecting inflammation and immune response, leading to gastric carcinogenesis. As an important component of transcriptome, non-coding RNAs (ncRNAs) have been proven to play crucial roles in the genesis and development of -induced GC. This review briefly described the effects of ncRNAs on -related GC from the perspective of inflammation and immune response, as well as their association with inflammatory reaction and immune microenvironment. We aim to explore the potential of ncRNAs as markers for the early diagnosis, prognosis, and treatment of -related GC. The ncRNAs involved in -related GC may all hold promise as novel therapeutic targets for immunotherapy.
（）是全球公认的胃癌（GC）致病因素之一。目前，尽管早期可根除感染，但与-相关的GC尚无明确的治疗方法和药物得到广泛认可。炎症和免疫反应是感染过程中自发的重要阶段。可能通过影响炎症和免疫反应介导免疫逃逸，导致胃癌发生。作为转录组的重要组成部分，非编码RNA（ncRNAs）已被证明在-诱导的GC的发生和发展中起关键作用。本综述从炎症和免疫反应的角度简要描述了ncRNAs对-相关GC的影响，以及它们与炎症反应和免疫微环境的关联。我们旨在探索ncRNAs作为-相关GC早期诊断、预后和治疗标志物的潜力。参与-相关GC的ncRNAs都有望成为免疫治疗的新型治疗靶点。
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