Department of Biology, Okayama University, Okayama, Japan.
JST-PRESTO, Japan Science and Technology Agency, Tokyo, Japan.
Brain Connect. 2023 Jun;13(5):307-314. doi: 10.1089/brain.2022.0044. Epub 2022 Sep 15.
To date, numerous studies have documented various alterations in resting brain activity in Alzheimer's disease (AD) and other neuropsychiatric diseases. In particular, disease-related alterations of functional connectivity (FC) in the resting state networks (RSN) have been documented. Altered FC in RSN is useful not only for interpreting the phenotype of diseases but also for diagnosing the diseases. More recently, several studies proposed the dynamics of resting-brain activity as a useful marker for detecting altered RSNs related to AD and other diseases. In this article, we review recent studies exploring alterations of static and dynamic functional connectivity in AD and other neuropsychiatric diseases. We then discuss how to utilize and interpret dynamics of FC for studying resting brain activity in diseases. In contrast to previous studies, which focused on FC calculated using an entire fMRI scan (static FC), newer studies focused on the temporal dynamics of FC within the scan (dynamic FC) to provide more sensitive measures to characterize RSNs. However, despite the increasing popularity of dynamic FC, several statistical investigations of dynamic FC cautioned that the results obtained in commonly used analyses for dynamic FC require careful interpretation. Although static and dynamic FC are likely to be a useful tool to detect altered RSN in patients affected by AD and other neuropsychiatric disorders, interpretation of altered dynamic FC in patients require special care. Impact statement We review recent studies of static and dynamic functional connectivity (dFC) in Alzheimer's disease and discuss interpretation of dFC.
迄今为止，已有大量研究记录了阿尔茨海默病（AD）和其他神经精神疾病中静息状态下大脑活动的各种改变。特别是，已经记录了与疾病相关的静息状态网络（RSN）中的功能连接（FC）改变。RSN 中改变的 FC 不仅有助于解释疾病的表型，而且有助于诊断疾病。最近，有几项研究提出了静息大脑活动的动力学作为检测与 AD 和其他疾病相关的改变的 RSN 的有用标记。在本文中，我们回顾了最近研究 AD 和其他神经精神疾病中静态和动态功能连接改变的研究。然后，我们讨论了如何利用和解释 FC 的动力学来研究疾病中的静息大脑活动。与以前的研究侧重于使用整个 fMRI 扫描计算的 FC（静态 FC）不同，新的研究侧重于扫描内 FC 的时间动力学（动态 FC），以提供更敏感的措施来描述 RSN。然而，尽管动态 FC 的普及程度不断提高，但对动态 FC 的几项统计研究警告说，通常用于动态 FC 的分析所获得的结果需要仔细解释。尽管静态和动态 FC 可能是检测 AD 患者和其他神经精神障碍患者中改变的 RSN 的有用工具，但对患者中改变的动态 FC 的解释需要特别注意。影响说明我们回顾了阿尔茨海默病的静态和动态功能连接（dFC）的最新研究，并讨论了 dFC 的解释。
