Universidade Federal de Pernambuco, Departamento Ciências farmacêuticas, CEP: 50740-520 Recife, PE, Brazil.
Universidade Federal de Pernambuco, Departamento Ciências farmacêuticas, CEP: 50740-520 Recife, PE, Brazil.
Environ Toxicol Pharmacol. 2022 Oct;95:103961. doi: 10.1016/j.etap.2022.103961. Epub 2022 Aug 19.
This work attempts to evaluate dermal exposure (DE) of farm workers to dimethoate after 4 h of routine application to a lemon plantation. Dimethoate was measured on the workers' clothes as well as in stratum corneum (SC) and in saliva. In vitro permeation tests (IVPT) were performed through rat, pig and human skin and pig buccal, esophageal and sublingual mucosas. The mean of dimethoate DE was 342.19 ± 487.14 mg/d, the percentage of toxic dose per hour was higher than the other pesticides, and the SC penetration factors ranged between 0.5 and 14.81 and 0.05-53.96 % for back of neck and arms respectively. In the supporting IVPT study, dimethoate absorption through human skin was 14.75 % and the default value in the absence of experimental data for this product is 70%. These results show that in family farming the deficiency of correct clothing during the application of pesticides leaves workers more vulnerable.
本研究旨在评估柠檬园常规施药 4 小时后，农民皮肤接触二甲基氧膦的情况。在工人的衣物、皮肤角质层和唾液中均检测到二甲基氧膦。通过大鼠、猪和人体皮肤以及猪口腔、食管和舌下黏膜进行体外渗透测试（IVPT）。二甲基氧膦的皮肤接触量均值为 342.19 ± 487.14 mg/d，每小时的毒性剂量百分比高于其他农药，颈部和手臂背部的皮肤角质层渗透因子分别在 0.5 至 14.81 以及 0.05 至 53.96 %之间。在辅助 IVPT 研究中，人体皮肤对二甲基氧膦的吸收率为 14.75 %，而该产品缺乏实验数据时的默认值为 70%。这些结果表明，在家庭农业中，施药过程中缺乏正确的服装会使工人更容易受到伤害。
