Department of Biology, School of Sciences and Humanities, Nazarbayev University, 53 Kabanbay Batyr Ave, 010000, Nur-Sultan, Republic of Kazakhstan.
Sino-German Joint Research Center on Agricultural Biology, State Key Laboratory of Crop Biology, College of Life Sciences, Shandong Agricultural University, Tai'an, 271018, China.
Sci Rep. 2022 Aug 22;12(1):14296. doi: 10.1038/s41598-022-15338-9.
Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase, with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development of anti-COVID-19 agents.
红花（Carthami flos）和西红花（Croci stigma）已被用作抗新冠病毒的中药，但作用机制尚不清楚。本研究通过分析活性化合物和化合物靶点网络、酶动力学测定、信号通路分析，应用网络药理学方法，探讨了其抗新冠病毒的潜在机制。我们发现两味草药均作用于包括激酶在内的信号通路，以响应炎症和病毒。此外，西红花可能由于与人类 ACE2 受体的高亲和力而具有抗病毒作用。红花和西红花的提取物表现出碱性磷酸酶的纳米酶/草药酶活性，并具有明显的荧光。因此，我们的数据表明红花在开发抗新冠病毒药物方面具有巨大的潜力。
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