Ghiasvand Reza, Rashidian Ali, Abaj Faezeh, Rafiee Masoumeh
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Iran.
Department of Industrial Engineering, Sharif University of Technology, Tehran, Iran.
Int J Vitam Nutr Res. 2023 Dec;93(6):535-558. doi: 10.1024/0300-9831/a000762. Epub 2022 Aug 23.
It is now becoming increasingly recognized that the effects of vitamin D supplementation may vary by several factors including vitamin D deficiency status, ethnicity, and/or the presence of genetic variants, which affect individual responses to supplementation. This study investigates the interaction between metabolic traits and circulating 25-hydroxyvitamin-D (25OHD) concentration with 4 polymorphisms of vitamin D receptor (VDR) including BsmI, ApaI, TaqI, FokI, and vitamin D supplementation. A systematic review and meta-analysis of papers until August 2021 on PubMed, The Cochrane Library, Scopus, Web of Science, Google Scholar, ProQuest, Science Direct, and Embase about the association between functionally relevant VDR variants and vitamin D supplementation on circulating 25OHD and metabolic traits. A total of 2994 cases from 16 randomized controlled trial (RCT) studies were included in meta-analyses. There were no significant changes in the serum concentrations of 25OHD and metabolic traits after vitamin D supplementation in different variants of BsmI, ApaI, TaqI, and FokI polymorphism in the VDR gene in the overall analysis (p>0.05). However, the results showed there is significant interaction between these above VDR polymorphisms and vitamin D supplement on serum 25OHD level after subgroup analyses based on the study duration, gender, age, BMI, health status, Hardy-Weinberg Equilibrium, PCR, and race (p<0.05). The present meta-analysis demonstrates that the effect of vitamin D supplementation on serum 25OHD and metabolic traits is independent of genetic variants of the VDR gene (BsmI, ApaI, TaqI, and FokI). However, future trials should consider inter-individual differences and, in particular, should aim to clarify whether certain subgroups of individuals may benefit from vitamin D supplementation in the context of metabolic health.
现在人们越来越认识到，补充维生素D的效果可能因多种因素而异，包括维生素D缺乏状况、种族和/或基因变异的存在，这些因素会影响个体对补充剂的反应。本研究调查了代谢特征与循环25-羟基维生素D（25OHD）浓度之间的相互作用，以及维生素D受体（VDR）的4种多态性，包括BsmI、ApaI、TaqI、FokI，和维生素D补充剂。对截至2021年8月发表在PubMed、Cochrane图书馆、Scopus、科学网、谷歌学术、ProQuest、科学Direct和Embase上的关于功能相关VDR变异与维生素D补充剂对循环25OHD和代谢特征的关联的论文进行系统综述和荟萃分析。荟萃分析共纳入了来自16项随机对照试验（RCT）研究的2994例病例。在总体分析中，VDR基因中BsmI、ApaI、TaqI和FokI多态性的不同变体在补充维生素D后，25OHD的血清浓度和代谢特征没有显著变化（p>0.05）。然而，结果显示，在基于研究持续时间、性别、年龄、BMI、健康状况、哈迪-温伯格平衡、PCR和种族进行亚组分析后，上述VDR多态性与维生素D补充剂对血清25OHD水平存在显著相互作用（p<0.05）。本荟萃分析表明，补充维生素D对血清25OHD和代谢特征的影响独立于VDR基因（BsmI、ApaI、TaqI和FokI）的基因变异。然而，未来的试验应考虑个体差异，特别是应旨在阐明在代谢健康背景下，某些个体亚组是否可能从补充维生素D中获益。
