H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Nat Prod Res. 2023 Jun;37(12):2018-2023. doi: 10.1080/14786419.2022.2112956. Epub 2022 Aug 23.
Phytochemical investigation of dried flower buds of (L.) Merr. & L.M.Perry. (clove) led to the isolation and identification of fourteen known compounds, oleanolic acid (), betulinic acid (), methyl benzoic acid (), sabrinic acid () eucalyptolic acid (), nigricin (), 3----coumaroylmaslinic acid (), methyl maslinate (), maslinic acid (), 3, 4, 5-trimethoxy-3',4'-,-methylideneflavellagic acid (), lantanone () 3,4,3'-trimethoxyellagic acid (), 11-oxo-oleanolic acid (), and -sitosterol-3---D-glucopyranoside (). Their structures were identified by H NMR, C NMR, Mass spectroscopic techniques, and comparison with the literature data. Compounds , and showed a strong mortality against root knot nematode, at 0.125% concentration after 72 hours (88-92% inhibition). Compound showed a good anti-glycation activity with IC = 142.0 ± 1.8 M when compared with standard, i.e. rutin (IC = 54.59 ± 2.20 M). Compound showed a comparable urease inhibitory activity (IC = 26.1 ± 0.19 M) with the positive control thiourea (IC = 24.5 ± 0.34 M).
对（L.）Merr. & L.M.Perry 的干花蕾进行植物化学研究，分离并鉴定了 14 种已知化合物，包括齐墩果酸（）、桦木酸（）、苯甲酸甲酯（）、Sabrinic 酸（）、桉叶醇酸（）、黑麦酮（）、3----香豆酰马尿酸（）、马尿酸甲酯（）、马尿酸（）、3,4,5-三甲氧基-3',4'-,-亚甲基二氢黄烷酮酸（）、拉坦酮（）、3,4,3'-三甲氧基鞣花酸（）、11-氧代齐墩果酸（）和-谷甾醇-3---D-吡喃葡萄糖苷（）。它们的结构通过 H NMR、C NMR、质谱技术以及与文献数据的比较来确定。化合物、和在 0.125%浓度下，72 小时后对根结线虫显示出很强的致死性（88-92%的抑制率）。与标准品芦丁（IC = 54.59 ± 2.20 M）相比，化合物显示出良好的抗糖化活性，IC = 142.0 ± 1.8 M。化合物显示出与阳性对照硫脲（IC = 24.5 ± 0.34 M）相当的脲酶抑制活性（IC = 26.1 ± 0.19 M）。
