从 J.R. Drumm 的心材中得到的一个新的木脂素和一个新的酚酸。

A new neolignan and a new phenolic acid from the heartwood of J.R. Drumm.

机构信息

Department of Chemistry, Faculty of Science, Center of Excellence in Natural Products Chemistry, Chulalongkorn University, Bangkok, Thailand.

Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan.

出版信息

Nat Prod Res. 2024 Jan-Feb;38(2):245-252. doi: 10.1080/14786419.2022.2116022. Epub 2022 Aug 23.

DOI:10.1080/14786419.2022.2116022

PMID:35997259

Abstract

One new neolignan () and one new phenolic compound (), together with four known compounds (- were isolated from the heartwood of . Their structures were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR and HRESIMS. The absolute configuration of was established based on the DP4+ protocol and by comparison of experimental and calculated ECD spectra. All isolated compounds were evaluated by DPPH assay for antioxidant activity, while compounds - were assayed using the MTT-based colorimetric assay for cytotoxicity against lung cancer cell line A549. In terms of antioxidant activity, and exhibited stronger activity (IC 14.91 ± 1.10 and 17.46 ± 0.16 μM, respectively) than the positive control, ascorbic acid (IC 30.20 ± 0.47 μM). Among the compounds tested for cytotoxicity, compound showed the highest activity, with an IC value of 26.04 ± 2.95 µM.

摘要

从的心材中分离得到一个新的木脂素（）和一个新的酚类化合物（），以及四个已知化合物（-。通过广泛的光谱分析，包括 1D 和 2D NMR 和 HRESIMS，确定了它们的结构。通过 DP4+ 方案和比较实验和计算的 ECD 光谱，确定了的绝对构型。所有分离得到的化合物均通过 DPPH 法测定抗氧化活性，而化合物 - 通过 MTT 比色法测定对肺癌细胞系 A549 的细胞毒性。在抗氧化活性方面，和表现出更强的活性（IC 14.91±1.10 和 17.46±0.16 μM，分别），优于阳性对照抗坏血酸（IC 30.20±0.47 μM）。在测试的具有细胞毒性的化合物中，化合物表现出最高的活性，IC 值为 26.04±2.95 μM。