Department of Public Health, University of Naples Federico II, Naples, Italy.
Department of Public Health, University of Naples Federico II, Naples, Italy.
Lung Cancer. 2022 Oct;172:53-64. doi: 10.1016/j.lungcan.2022.08.004. Epub 2022 Aug 10.
Liquid biopsy has revolutionized the management of cancer patients. In particular, liquid biopsy-based testing has proven to be highly beneficial for identifying actionable cancer markers, especially when solid tissue biopsies are insufficient or unattainable. Beyond the predictive role, liquid biopsy may be a useful tool for comprehensive tumor genotyping, identification of emergent resistance mechanisms, monitoring of minimal residual disease, early detection, and cancer interception. The application of next generation sequencing to liquid biopsy has led to the "quantum leap" of predictive molecular pathology. Here, we review the evolving role of liquid biopsy in lung cancer.
液体活检改变了癌症患者的管理方式。特别是，液体活检检测已被证明对鉴定有治疗作用的癌症标志物非常有益，尤其是在组织活检不足或无法进行时。除了预测作用，液体活检还可能是全面肿瘤基因分型、鉴定新出现的耐药机制、监测微小残留疾病、早期检测和癌症干预的有用工具。下一代测序在液体活检中的应用使预测分子病理学取得了“质的飞跃”。在这里，我们回顾了液体活检在肺癌中的作用。
