Dissecting integrated indices of multiple biomarker responses: Think before use.

The multiple biomarker approach is an effective tool to study the responses of aquatic organisms to contaminants. Summarizing multiple biomarker responses for facilitated communication of research findings has been aided by some integrated indices. Here we explain how existing integrated indices were built and why they turn out to be the wheel reinvented. We discuss the role of integrated indices in ecological risk assessment and recommend some changes in summarizing multiple biomarker results. Integr Environ Assess Manag 2023;19:302-311. © 2022 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).