Locatelli A, Treggiari E, Innocenti M, Romanelli G
Centro Specialistico Veterinario, 20141, Milan, Italy.
J Small Anim Pract. 2022 Dec;63(12):897-903. doi: 10.1111/jsap.13546. Epub 2022 Aug 24.
To describe ultrasound-guided microwave ablation as a minimally invasive treatment option for primary or metastatic hepatocellular carcinomas.
Four client-owned dogs underwent percutaneous ultrasound-guided microwave ablation of three primary and one metastatic hepatocellular carcinoma, diagnosed on cytology/histopathology. In each case, multiple ultrasound-guided thermal lesions were created in a 10 to 40 minutes ablation at 30 to 35 W. Real-time monitoring was performed using 10 MHz diagnostic ultrasound transducers. The procedures were performed without complication and CT scans or abdominal ultrasounds were repeated immediately after. Patients were discharged on oral analgesia on the same day or 24 hours later.
Hepatocellular carcinomas were successfully ablated, which in some cases resulted in an improvement in clinical signs and laboratory values. The patients were followed up for a time ranging between 39 and 649 days and no evidence of disease progression was found. Three out of four patients are still alive at the time of writing.
In these four patients, minimally invasive ultrasound-guided microwave ablation was feasible and resulted in no immediate complications. Regular imaging follow-up is recommended after the procedure and further studies on microwave ablation are warranted to establish its effectiveness in dogs with hepatocellular carcinomas.
描述超声引导下微波消融作为原发性或转移性肝细胞癌的一种微创治疗选择。
4只客户拥有的犬接受了经皮超声引导下对3例原发性和1例转移性肝细胞癌的微波消融，这些肿瘤经细胞学/组织病理学诊断。在每例病例中，以30至35瓦的功率在10至40分钟的消融过程中创建多个超声引导下的热损伤灶。使用10兆赫诊断超声换能器进行实时监测。手术过程无并发症，术后立即重复进行CT扫描或腹部超声检查。患者在同一天或24小时后口服镇痛药出院。
肝细胞癌成功消融，在某些情况下导致临床症状和实验室值有所改善。对患者进行了39至649天的随访，未发现疾病进展的证据。在撰写本文时，4例患者中有3例仍存活。
在这4例患者中，微创超声引导下微波消融是可行的，且未导致即刻并发症。建议术后进行定期影像学随访，有必要对微波消融进行进一步研究以确定其在犬肝细胞癌中的有效性。
