Alférez María Dolores, Corda Andrea, de Blas Ignacio, Gago Lucas, Fernandes Telmo, Rodríguez-Piza Ignacio, Balañá Beatriz, Pentcheva Plamena, Caruncho Javier, Barbero-Fernández Alicia, Llinás Jorge, Rivas David, Escudero Amaia, Gómez-Ochoa Pablo
VetCorner Unavets, 50012 Zaragoza, Spain.
Department of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy.
Animals (Basel). 2024 Dec 20;14(24):3682. doi: 10.3390/ani14243682.
Nasal carcinomas in dogs are locally invasive neoplasms with a low metastatic rate that pose significant treatment challenges due to their location and aggressiveness. This study evaluates the safety, feasibility, and therapeutic outcomes of computed tomography-guided radiofrequency ablation (CT-guided RFA) in 15 dogs diagnosed with nasal adenocarcinoma. All patients underwent staging and histopathological diagnosis before treatment. CT-guided RFA achieved a significant tumor volume reduction (82.8%) and improvement in clinical signs such as nasal discharge, epistaxis, and respiratory distress, without complications. Post-RFA CT examinations demonstrated a significant decrease in Hounsfield units and tumor volume. This study has shown that CT-guided RFA is an effective cytoreductive option for minimally invasive management of nasal adenocarcinomas in dogs, particularly when traditional therapies like radiation therapy or surgery are not feasible.
犬鼻癌是具有低转移率的局部浸润性肿瘤，由于其位置和侵袭性，给治疗带来了重大挑战。本研究评估了计算机断层扫描引导下射频消融（CT引导下RFA）对15只诊断为鼻腺癌的犬的安全性、可行性和治疗效果。所有患者在治疗前均进行了分期和组织病理学诊断。CT引导下RFA显著降低了肿瘤体积（82.8%），并改善了诸如鼻分泌物、鼻出血和呼吸窘迫等临床症状，且无并发症。RFA术后CT检查显示亨氏单位和肿瘤体积显著减小。本研究表明，CT引导下RFA是犬鼻腺癌微创治疗的一种有效的细胞减灭选择，特别是在放射治疗或手术等传统疗法不可行时。
