[阿托伐他汀与考比司他药物相互作用导致的横纹肌溶解症]
[Rhabdomyolysis due to drug-drug interaction of atorvastatin and cobicistat].
作者信息
Intert E, Krause M, Hennersdorf F, Knop K, Rosenkranz T
机构信息
Abteilung für Innere Medizin, Schön Klinik Hamburg Eilbek, Dehnhaide 120, 22081, Hamburg, Deutschland.
Muskelhistologisches Labor, Asklepios Klinik St. Georg, Hamburg, Deutschland.
出版信息
Inn Med (Heidelb). 2022 Nov;63(11):1189-1193. doi: 10.1007/s00108-022-01377-x. Epub 2022 Aug 24.
A 53-year-old man presented with rhabdomyolysis and acute kidney injury. The symptoms were presumably caused by a drug-drug interaction between an antiretroviral drug combination and atorvastatin. As a booster, cobicistat can also increase the toxicity of statins via inhibition of the enzyme cytochrome p450 3A4 (CYP3A4). After stopping atorvastatin and after intravenous fluid therapy, the symptoms regressed completely.
一名53岁男性出现横纹肌溶解和急性肾损伤。这些症状可能是由抗逆转录病毒药物组合与阿托伐他汀之间的药物相互作用引起的。作为一种增效剂，考比司他也可通过抑制细胞色素P450 3A4（CYP3A4）酶增加他汀类药物的毒性。停用阿托伐他汀并进行静脉补液治疗后，症状完全消退。
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