State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Gut Microbes. 2022 Jan-Dec;14(1):2114739. doi: 10.1080/19490976.2022.2114739.
Hypervirulent (hvKp) can cause serious infections and has been increasingly reported clinically. However, we still lack the knowledge to what degree hvKp colonize the community. In this study, we investigated colonization of hvKp in healthy human gut and the relationship between gut hvKp and clinically important invasive strains. We compile global genomes of gut for in-depth genetic analysis and found most hvKp genomes originated from Chinese datasets; therefore, we collected gut isolates from healthy people around China. The results revealed a moderate carriage rate of hvKp in the healthy population (4%-5.19%). Phylogenetic analysis indicated a close relationship between gut hvKp and fatal clinical strains. These results demonstrate that the human gut may serve as a reservoir of hvKp and that gut hvKp can play a role in infection of other body parts.
高毒力（hvKp）能够引起严重感染，并且在临床上的报道越来越多。然而，我们仍然缺乏有关hvKp 在社区中定植程度的知识。在这项研究中，我们调查了健康人体肠道中 hvKp 的定植情况，以及肠道 hvKp 与临床上重要的侵袭性菌株之间的关系。我们编译了肠道的全球基因组，进行深入的遗传分析，发现大多数 hvKp 基因组源自中国数据集；因此，我们从中国各地的健康人群中收集了肠道分离株。结果显示，健康人群中 hvKp 的携带率中等（4%-5.19%）。系统发育分析表明，肠道 hvKp 与致命性临床菌株密切相关。这些结果表明，人类肠道可能是 hvKp 的储库，肠道 hvKp 可能在感染身体其他部位中发挥作用。
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