Kuang Xiaoxian, Shen Juntao, Zheng Linggang, Duan Yi, Ma Yingfei, Leung Elaine Lai-Han, Dai Lei
Cancer Center, Faculty of Health Science, and MOE Frontiers Science Center for Precision Oncology, University of Macau, Taipa, China.
CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Eng Microbiol. 2025 Jan 6;5(1):100189. doi: 10.1016/j.engmic.2025.100189. eCollection 2025 Mar.
As our understanding of the role of the gut microbiome in human diseases deepens, precision engineering of the gut microbiome using bacteriophages has gained significant attention. Herein, we review the recent advances in bacteriophage-mediated modulation of the gut microbiome, discuss approaches at the ecological and genetic levels, and summarize the challenges and strategies pertinent to each level of intervention. Drawing on the structural attributes of bacteriophages in the context of precision engineering, we examined the latest developments in the field of phage administration. Gaining a nuanced understanding of microbiome manipulation will yield tailored strategies and technologies. This could revolutionize the prevention and treatment of diseases linked to gut pathogens and offer new avenues for the therapeutic use of bacteriophages.
随着我们对肠道微生物群在人类疾病中作用的理解不断深入，利用噬菌体对肠道微生物群进行精准工程改造已受到广泛关注。在此，我们回顾了噬菌体介导的肠道微生物群调节的最新进展，讨论了生态和遗传层面的方法，并总结了与每个干预层面相关的挑战和策略。基于精准工程背景下噬菌体的结构特性，我们研究了噬菌体给药领域的最新进展。对微生物群操纵有细致入微的理解将产生量身定制的策略和技术。这可能会彻底改变与肠道病原体相关疾病的预防和治疗，并为噬菌体的治疗应用开辟新途径。
