Taskinen M R, Nikkilä E A
Metabolism. 1987 Jul;36(7):625-30. doi: 10.1016/0026-0495(87)90144-2.
The effect of a ten-day caloric restriction period and of subsequent refeeding on adipose tissue lipoprotein lipase (LPL) activity was studied in 14 moderately obese women. The enzyme assays were made from subcutaneous fat taken from three separate regions (gluteal, femoral, and abdominal) after overnight fasting and from one region also after a standard meal. There was a close correlation between the activities measured from the different subcutaneous sites. The caloric restriction was followed by a decrease of the basal LPL activity to one fifth of the value recorded during the isocaloric diet. However, the relative postprandial increase of LPL activity was greater during the low-calorie diet than during the isocaloric diet. During refeeding the basal LPL activity rose but remained at a lower level than before the caloric restriction. The postprandial LPL response was markedly exaggerated after ten days of refeeding (21% increase before dieting and 250% after refeeding). The changes of LPL during caloric restriction and subsequent refeeding were not correlated to plasma insulin levels. The mechanism of the exaggerated LPL response to meal during refeeding remains obscure.
对14名中度肥胖女性研究了为期10天的热量限制期及随后再进食对脂肪组织脂蛋白脂肪酶（LPL）活性的影响。酶活性测定取自三个不同部位（臀、股和腹部）的皮下脂肪，其中过夜禁食后取一次，标准餐后也从一个部位取一次。不同皮下部位测得的活性之间存在密切相关性。热量限制后，基础LPL活性降至等热量饮食期间记录值的五分之一。然而，低热量饮食期间餐后LPL活性的相对增加幅度大于等热量饮食期间。再进食期间，基础LPL活性上升，但仍低于热量限制前的水平。再进食10天后，餐后LPL反应明显增强（节食前增加21%，再进食后增加250%）。热量限制及随后再进食期间LPL的变化与血浆胰岛素水平无关。再进食期间对餐食的LPL反应增强的机制仍不清楚。
