Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Kuantan, Malaysia.
J Neuroeng Rehabil. 2022 Aug 24;19(1):94. doi: 10.1186/s12984-022-01072-w.
Hospital-based stroke rehabilitation for stroke survivors in developing countries may be limited by staffing ratios and length of stay that could hamper recovery potential. Thus, a home-based, gamified rehabilitation system (i.e., IntelliRehab) was tested for its ability to increase cerebral blood flow (CBF), and the secondary impact of changes on the upper limb motor function and functional outcomes.
To explore the effect of IntelliRehab on CBF in chronic stroke patients and its correlation with the upper limb motor function.
Two-dimensional pulsed Arterial Spin Labelling (2D-pASL) was used to obtain CBF images of stable, chronic stroke subjects (n = 8) over 3-months intervention period. CBF alterations were mapped, and the detected differences were marked as regions of interest. Motor functions represented by Fugl-Meyer Upper Extremity Assessment (FMA) and Stroke Impact Scale (SIS) were used to assess the primary and secondary outcomes, respectively.
Regional CBF were significantly increased in right inferior temporal gyrus and left superior temporal white matter after 1-month (p = 0.044) and 3-months (p = 0.01) of rehabilitation, respectively. However, regional CBF in left middle fronto-orbital gyrus significantly declined after 1-month of rehabilitation (p = 0.012). Moreover, SIS-Q7 and FMA scores significantly increased after 1-month and 3-months of rehabilitation. There were no significant correlations, however, between CBF changes and upper limb motor function.
Participants demonstrated improved motor functions, supporting the benefit of using IntelliRehab as a tool for home-based rehabilitation. However, within-participant improvements may have limited potential that suggests the need for a timely administration of IntelliRehab to get the maximum capacity of improvement.
发展中国家的脑卒中幸存者的医院基础康复可能受到人员配备比例和住院时间的限制，从而阻碍了康复潜力的发挥。因此，测试了一种基于家庭的、游戏化的康复系统（即 IntelliRehab），以了解其增加脑血流（CBF）的能力，以及这种变化对上肢运动功能和功能结果的二级影响。
探讨 IntelliRehab 对慢性脑卒中患者 CBF 的影响及其与上肢运动功能的相关性。
使用二维动脉自旋标记（2D-pASL）在 3 个月的干预期间获得稳定的慢性脑卒中患者的 CBF 图像。映射 CBF 变化，并将检测到的差异标记为感兴趣的区域。使用 Fugl-Meyer 上肢评估（FMA）和脑卒中影响量表（SIS）来评估主要和次要结果，分别代表运动功能。
经过 1 个月（p=0.044）和 3 个月（p=0.01）的康复后，右侧下颞叶和左侧上颞叶白质的局部 CBF 显著增加。然而，左侧中额眶回的局部 CBF 在康复 1 个月后显著下降（p=0.012）。此外，SIS-Q7 和 FMA 评分在康复 1 个月和 3 个月后显著增加。然而，CBF 变化与上肢运动功能之间没有显著相关性。
参与者的运动功能得到了改善，这支持了将 IntelliRehab 用作家庭康复工具的益处。然而，个体内的改善可能潜力有限，这表明需要及时进行 IntelliRehab 治疗，以获得最大的改善能力。
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