文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

经颅磁刺激治疗脑卒中后运动功能恢复的疗效:系统评价。

The effectiveness of theta burst stimulation for motor recovery after stroke: a systematic review.

机构信息

Beijing Xiaotangshan Hospital, Beijing, China.

Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Institute of Sport, Exercise & Health, Tianjin University of Sport, Tianjin, China.

出版信息

Eur J Med Res. 2024 Nov 29;29(1):568. doi: 10.1186/s40001-024-02170-2.


DOI:10.1186/s40001-024-02170-2
PMID:39609900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11605871/
Abstract

BACKGROUND: Stroke is the second leading cause of death and the third leading cause of disability worldwide. Motor dysfunction is a common sequela, which seriously affects the lives of patients. Theta burst stimulation (TBS) is a new transcranial magnetic therapy for improving motor dysfunction after stroke. However, there remains a lack of studies on the mechanism, theoretical model, and effectiveness of TBS in improving motor dysfunction following stroke. OBJECTIVE: This paper provides a comprehensive overview and assessment of the current impact of TBS on motor rehabilitation following stroke and analyzes potential factors contributing to treatment effect disparities. The aim is to offer recommendations for further refining the TBS treatment approach in subsequent clinical studies while also furnishing evidence for devising tailored rehabilitation plans for stroke patients. METHODS: This study was conducted following PRISMA guidelines. PubMed, Embase, Web of Science, and the Cochrane Library were searched systematically from the establishment of the database to February 2024. Relevant studies using TBS to treat patients with motor dysfunction after stroke will be included. Data on study characteristics, interventions, outcome measures, and primary outcomes were extracted. The Modified Downs and Black Checklist was used to assess the potential bias of the included studies, and a narrative synthesis of the key findings was finally conducted. RESULTS: The specific mechanism of TBS in improving motor dysfunction after stroke has not been fully elucidated, but it is generally believed that TBS can improve the functional prognosis of patients by regulating motor cortical excitability, inducing neural network reorganization, and regulating cerebral circulation metabolism. Currently, most relevant clinical studies are based on the interhemispheric inhibition model (IHI), the vicariation model, and the bimodal balance-recovery model. Many studies have verified the effectiveness of TBS in improving the motor function of stroke patients, but the therapeutic effect of some studies is controversial. CONCLUSION: Our results show that TBS has a good effect on improving motor function in stroke patients, but more large-scale, high-quality, multicenter studies are still necessary in the future to further clarify the mechanism of TBS and explore the optimal TBS treatment.

摘要

背景:脑卒中是全球范围内第二大致死原因和第三大致残原因。运动功能障碍是常见的后遗症,严重影响患者的生活。θ爆发刺激(TBS)是一种新的经颅磁刺激治疗方法,可改善脑卒中后的运动功能障碍。然而,目前关于 TBS 改善脑卒中后运动功能障碍的机制、理论模型和疗效仍缺乏研究。

目的:本文全面综述和评估 TBS 对脑卒中后运动康复的影响,并分析导致治疗效果差异的潜在因素。旨在为今后的临床研究进一步优化 TBS 治疗方法提供建议,同时为脑卒中患者制定个体化康复方案提供依据。

方法:本研究按照 PRISMA 指南进行。系统检索 PubMed、Embase、Web of Science 和 Cochrane Library 从建库至 2024 年 2 月的相关文献。纳入使用 TBS 治疗脑卒中后运动功能障碍患者的研究。提取研究特征、干预措施、结局指标和主要结局数据。采用改良的 Downs 和 Black 清单评估纳入研究的潜在偏倚,并对关键发现进行叙述性综合。

结果:TBS 改善脑卒中后运动功能障碍的具体机制尚未完全阐明,但普遍认为 TBS 通过调节运动皮质兴奋性、诱导神经网络重组和调节脑循环代谢来改善患者的功能预后。目前,大多数相关临床研究基于双侧半球抑制模型(IHI)、代偿模型和双模态平衡恢复模型。许多研究已经验证了 TBS 改善脑卒中患者运动功能的有效性,但一些研究的治疗效果存在争议。

结论:本研究结果表明,TBS 对改善脑卒中患者的运动功能有较好的效果,但未来仍需要更多大规模、高质量、多中心的研究进一步阐明 TBS 的作用机制,并探索最佳的 TBS 治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5077/11605871/753f341efa4a/40001_2024_2170_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5077/11605871/753f341efa4a/40001_2024_2170_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5077/11605871/753f341efa4a/40001_2024_2170_Fig1_HTML.jpg

相似文献

[1]
The effectiveness of theta burst stimulation for motor recovery after stroke: a systematic review.

Eur J Med Res. 2024-11-29

[2]
Theta burst stimulation for enhancing upper extremity motor functions after stroke: a systematic review of clinical and mechanistic evidence.

Rev Neurosci. 2024-8-27

[3]
Yoga for stroke rehabilitation.

Cochrane Database Syst Rev. 2017-12-8

[4]
Transcranial direct current stimulation (tDCS) for improving activities of daily living, and physical and cognitive functioning, in people after stroke.

Cochrane Database Syst Rev. 2016-3-21

[5]
Evidence for Intermittent Theta Burst Transcranial Magnetic Stimulation for Dysphagia after Stroke: A Systematic Review and Meta-analysis.

Dysphagia. 2025-2

[6]
[Volume and health outcomes: evidence from systematic reviews and from evaluation of Italian hospital data].

Epidemiol Prev. 2013

[7]
Nutritional therapy for reducing disability and improving activities of daily living in people after stroke.

Cochrane Database Syst Rev. 2024-8-15

[8]
Examining the effectiveness of motor imagery combined with non-invasive brain stimulation for upper limb recovery in stroke patients: a systematic review and meta-analysis of randomized clinical trials.

J Neuroeng Rehabil. 2024-11-30

[9]
Virtual reality for stroke rehabilitation.

Cochrane Database Syst Rev. 2025-6-20

[10]
The effect of time spent in rehabilitation on activity limitation and impairment after stroke.

Cochrane Database Syst Rev. 2021-10-25

引用本文的文献

[1]
Immediate Neuroplastic Changes in the Cortex After iTBS on the Cerebellum of Stroke Patients: A Preliminary fNIRS Study.

Neural Plast. 2025-6-6

[2]
Metabolic and immune heterogeneity in stroke: Insights into subtype identification and biomarker discovery.

PLoS One. 2025-5-21

[3]
The effect of theta burst stimulation (TBS) on aphasia in stroke patients: a protocol of systematic review and meta-analysis.

Syst Rev. 2025-4-1

本文引用的文献

[1]
Effects of physical therapy modalities for motor function, functional recovery, and post-stroke complications in patients with severe stroke: a systematic review update.

Syst Rev. 2024-10-28

[2]
Ischemic Stroke: Pathophysiology and Evolving Treatment Approaches.

Neurosci Insights. 2024-10-22

[3]
Robot-assisted therapy in stratified intervention: a randomized controlled trial on poststroke motor recovery.

Front Neurol. 2024-9-26

[4]
Virtual reality in stroke recovery: a meta-review of systematic reviews.

Bioelectron Med. 2024-10-5

[5]
Gamified Practice Improves Paretic Arm Motor Behavior in Individuals With Stroke.

Neurorehabil Neural Repair. 2024-12

[6]
Effect and optimal exercise prescription of robot-assisted gait training on lower extremity motor function in stroke patients: a network meta-analysis.

Neurol Sci. 2025-3

[7]
Evidence that robot-assisted gait training modulates neuroplasticity after stroke: An fMRI pilot study based on graph theory analysis.

Brain Res. 2024-11-1

[8]
Theta burst stimulation for enhancing upper extremity motor functions after stroke: a systematic review of clinical and mechanistic evidence.

Rev Neurosci. 2024-8-27

[9]
A systematic-search-and-review of registered pharmacological therapies investigated to improve neuro-recovery after a stroke.

Front Neurol. 2024-1-31

[10]
Intermittent Theta-Burst Stimulation for Stroke: Primary Motor Cortex Versus Cerebellar Stimulation: A Randomized Sham-Controlled Trial.

Stroke. 2024-1

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索