Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Neuroimage Clin. 2022;35:103145. doi: 10.1016/j.nicl.2022.103145. Epub 2022 Aug 5.
In the present study, we aimed to investigate the resting-state functional connectivity (RS-FC) of the globus pallidus (GP) in patients with amyotrophic lateral sclerosis (ALS) compared to healthy controls, and the relationship between RS-FC changes and disgust recognition. Twenty-six pure-motor ALS patients and 52 healthy controls underwent RS functional MRI and a neuropsychological assessment including the Comprehensive Affect Testing System. A seed-based RS-FC analysis was performed between the left and right GP and the rest of the brain and compared between groups. Correlations between RS-FC significant changes and subjects' performance in recognizing disgust were tested. Compared to controls, patients were significantly less able to recognize disgust. In ALS compared to controls, the seed-based analysis showed: reduced RS-FC between bilateral GP and bilateral middle and superior frontal and middle cingulate gyri, and increased RS-FC between bilateral GP and bilateral postcentral, supramarginal and superior temporal gyri and Rolandic operculum. Decreased RS-FC was further observed between left GP and left middle and inferior temporal gyri and bilateral caudate; and increased RS-FC was also shown between right GP and left lingual and fusiform gyri. In patients and controls, lower performance in recognizing disgust correlated with reduced RS-FC between left GP and left middle and inferior temporal gyri. In pure-motor ALS patients, we demonstrated altered RS-FC between GP and the rest of the brain. The reduced left pallidum-temporo-striatal RS-FC may have a role in the lower ability of patients in recognizing disgust.
在本研究中，我们旨在研究肌萎缩侧索硬化症 (ALS) 患者与健康对照组之间苍白球的静息态功能连接 (RS-FC)，以及 RS-FC 变化与厌恶识别之间的关系。26 名单纯运动性 ALS 患者和 52 名健康对照者接受了 RS 功能 MRI 和神经心理学评估，包括综合情感测试系统。在组间进行了左、右苍白球与大脑其余部分之间的基于种子的 RS-FC 分析。测试了 RS-FC 显著变化与受试者识别厌恶能力之间的相关性。与对照组相比，患者识别厌恶的能力明显降低。与对照组相比，ALS 患者的基于种子的分析显示：双侧苍白球与双侧额中回和中央旁小叶、双侧中央后回、缘上回和颞上回以及 Rolandic 岛盖之间的 RS-FC 降低，双侧苍白球与双侧中央后回、缘上回和颞上回以及 Rolandic 岛盖之间的 RS-FC 增加。还观察到左侧苍白球与左侧颞中回和颞下回以及双侧尾状核之间的 RS-FC 进一步减少；右侧苍白球与左侧舌回和梭状回之间的 RS-FC 也增加。在患者和对照组中，识别厌恶的能力越低，与左侧苍白球与左侧颞中回和颞下回之间的 RS-FC 减少有关。在单纯运动性 ALS 患者中，我们证明了苍白球与大脑其余部分之间的 RS-FC 发生改变。左侧苍白球-颞叶-纹状体 RS-FC 的减少可能与患者识别厌恶的能力降低有关。
