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TDP-43 对海马亚区形态计量学和认知的独特影响。

The unique effect of TDP-43 on hippocampal subfield morphometry and cognition.

机构信息

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

出版信息

Neuroimage Clin. 2022;35:103125. doi: 10.1016/j.nicl.2022.103125. Epub 2022 Jul 25.

DOI:10.1016/j.nicl.2022.103125
PMID:36002965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9421500/
Abstract

• We explored TDP-43 burden and hippocampal surface deformation. • TDP-43 was uniquely associated with inward deformation in the hippocampus. • Deformation patterns account for co-existing disease showing TDP-43′s unique effect. • Deformation was significantly correlated with cognition scores.

摘要

• 我们研究了 TDP-43 负担和海马体表面变形。 • TDP-43 与海马体内向变形具有独特的相关性。 • 变形模式解释了共存疾病，表明 TDP-43 具有独特的影响。 • 变形与认知评分显著相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2965/9421500/2020192ff417/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2965/9421500/2020192ff417/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2965/9421500/2020192ff417/gr1.jpg

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