Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Cephalalgia. 2022 Dec;42(14):1532-1542. doi: 10.1177/03331024221120054. Epub 2022 Aug 24.
To compare the clinical profiles between male and female cluster headache patients from a large cohort.
This hospital-based study enrolled patients diagnosed with cluster headache between 1997 to 2021. Participants completed structured questionnaires collecting information on demographics, clinical profiles, and quality of life. Treatment regimens and effectiveness were determined through medical chart review. All variables were compared between the sexes.
In total, 798 patients (M/F:659/139) were enrolled. The male-to-female ratio was 4.7:1 for the full study period, but it declined from 5.2:1 to 4.3:1 for patients enrolled before and after 2010, respectively. The frequencies of chronic cluster headache (M:1.2%, F:1.4%) and aura (M:0.3%, F:0.7%) were low but similar between the sexes. Most headache features showed no difference between men and women. Female patients had significantly longer attack duration, shorter inter-bout duration, higher frequencies for eyelid edema, nausea and vomiting and lower frequencies for conjunctival injection and pacing. Sex difference did not influence headache-associated disability, anxiety, or depression, but poor sleep quality was significantly more common in women. Among menstruating women, 22/122 (18.0%) reported worsening headaches during menses. The effectiveness of treatment was similar between the sexes.
Despite a decline of male-to-female ratio in the past two decades, most clinical profiles were similar between the sexes.
比较大样本量的男性和女性丛集性头痛患者的临床特征。
本项基于医院的研究纳入了 1997 年至 2021 年间被诊断为丛集性头痛的患者。参与者完成了收集人口统计学、临床特征和生活质量信息的结构化问卷。通过病历审查确定治疗方案和疗效。比较了两性之间的所有变量。
共纳入 798 名患者（男/女：659/139）。在整个研究期间，男女比例为 4.7:1，但在 2010 年前和后分别登记的患者中，该比例从 5.2:1降至 4.3:1。慢性丛集性头痛（男：1.2%，女：1.4%）和先兆（男：0.3%，女：0.7%）的发生率较低，但两性之间相似。大多数头痛特征在男性和女性之间没有差异。女性患者的发作持续时间明显更长，发作间期更短，眼睑水肿、恶心和呕吐的频率更高，结膜充血和踱步的频率更低。性别差异不影响头痛相关的残疾、焦虑或抑郁，但女性的睡眠质量明显更差。在月经期的女性中，22/122（18.0%）报告头痛在经期加重。两性之间的治疗效果相似。
尽管在过去二十年中男性与女性的比例有所下降，但两性的大多数临床特征仍相似。
