Calandre Elena P, Ordoñez-Carrasco Jorge L, Slim Mahmoud, Rico-Villademoros Fernando, Garcia-Leiva Juan M
Institute of neurosciences, University of Granada, 18016 Granada, Spain.
Department of Psychology and Sociology, University of Zaragoza (Campus Teruel), 4403 Teruel, Spain.
J Oral Facial Pain Headache. 2024 Mar;38(1):32-39. doi: 10.22514/jofph.2024.004. Epub 2024 Mar 12.
The aim was to describe the comorbidity and impact of fibromyalgia and/or migraine on patients with cluster headache. Comorbid diseases can exacerbate the physical and psychological burden experienced by patients. The comorbidities of cluster headache have been scarcely investigated, with the exception of migraine, which is well-known to coexist with cluster headache. In contrast, the comorbidity of migraine and fibromyalgia has been well investigated and firmly established. An internet survey was uploaded to the webpage of a cluster headache patient association. The survey collected sociodemographic and clinical data, and patients completed questionnaires that assessed depression, sleep quality, health-related quality of life, and health care resource utilization (HCRU) over the preceding six months. Differences in total depression, sleep quality, and health-related quality of life scores among the groups were analyzed with the Kruskal-Wallis test, and differences in HCRU were analyzed with the chi-square test. Ninety-one patients with cluster headache participated in the survey; 39 (42.9%) experienced only cluster headache, 15 (16.5%) experienced cluster headache and migraine, 10 (11%) experienced cluster headache and fibromyalgia, and 27 (29.7%) experienced cluster headache with comorbid fibromyalgia and migraine. Moderate depression scores and positive suicidal ideation were found across all subgroups. Sleep quality and health-related quality of life were consistently poor across the different subgroups, with the cluster headache with comorbid fibromyalgia and migraine subgroup showing significantly lower scores. Heavy use of health care resources was observed across all subgroups, with no notable differences among them. The comorbidity of cluster headache with fibromyalgia and/or migraine does not seem to be infrequent. This comorbidity substantially increases the psychosocial burden experienced by patients and decreases their overall quality of life.
目的是描述纤维肌痛和/或偏头痛对丛集性头痛患者的共病情况及影响。共病会加重患者所经历的身心负担。除了众所周知与丛集性头痛共存的偏头痛外，丛集性头痛的共病情况鲜有研究。相比之下，偏头痛和纤维肌痛的共病情况已得到充分研究并确凿认定。一项网络调查被上传至一个丛集性头痛患者协会的网页。该调查收集了社会人口统计学和临床数据，患者完成了评估前六个月内抑郁、睡眠质量、健康相关生活质量以及医疗资源利用（HCRU）情况的问卷。采用Kruskal-Wallis检验分析各组间总抑郁、睡眠质量和健康相关生活质量得分的差异，采用卡方检验分析HCRU的差异。91名丛集性头痛患者参与了该调查；39名（42.9%）仅患有丛集性头痛，15名（16.5%）患有丛集性头痛和偏头痛，10名（11%）患有丛集性头痛和纤维肌痛，27名（29.7%）患有丛集性头痛且合并纤维肌痛和偏头痛两种疾病。在所有亚组中均发现有中度抑郁评分和积极的自杀意念。不同亚组的睡眠质量和健康相关生活质量一直较差，其中合并纤维肌痛和偏头痛的丛集性头痛亚组得分显著更低。在所有亚组中均观察到大量使用医疗资源的情况，各亚组之间无显著差异。丛集性头痛与纤维肌痛和/或偏头痛的共病情况似乎并不少见。这种共病显著增加了患者所经历的心理社会负担，并降低了他们的总体生活质量。
