Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Curr Pain Headache Rep. 2024 May;28(5):427-438. doi: 10.1007/s11916-024-01229-3. Epub 2024 Mar 5.
Previous studies have indicated a possible link between the prevalence of cluster headache (CH) and sunlight exposure. However, this theory has yet to be tested systemically. In this article, we aim to examine how latitude affects the prevalence and phenotypes of CH.
To our knowledge, there is by far no article describing the effect of latitude on disease phenotype; thus, we performed a literature review. We noted positive effects of latitude on 1-year prevalence, the proportion of chronic CH, and the proportion of miosis and/or ptosis. Latitude may affect the phenotypic presentations of cluster headache, probably partially mediated via temperature and sunlight variations. Still, other factors, such as environmental exposure to smoking and the genetic difference between the Eastern and Western populations, may participate in the pathogenesis and clinical manifestations of CH.
既往研究表明丛集性头痛（CH）的患病率与阳光暴露可能存在关联。然而，该理论尚未得到系统验证。本文旨在研究纬度如何影响 CH 的患病率和表型。
据我们所知，目前尚无描述纬度对疾病表型影响的文章；因此，我们进行了文献复习。我们注意到纬度对 1 年患病率、慢性 CH 比例和瞳孔缩小和/或上睑下垂比例有正向影响。纬度可能会影响丛集性头痛的表型表现，可能部分通过温度和阳光变化介导。然而，其他因素，如吸烟的环境暴露和东西方人群的遗传差异，可能参与 CH 的发病机制和临床表现。
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