Zhou Qing, Yan Pingping, Shi Haiming, Yan Ping
Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
Front Surg. 2022 Aug 8;9:890116. doi: 10.3389/fsurg.2022.890116. eCollection 2022.
Bariatric surgery is an effective method for severe obesity and its related comorbidities, in which inflammation plays a crucial role. The aim of this study was to investigate the changes of Neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) in patients undergoing laparoscopic sleeve gastrectomy (LSG) and to explore the related factors including gender.
We retrospectively included 72 patients undergoing LSG in our hospital from 2017 to 2020. Clinical information, laboratory investigations as well as parameters derived from traditional and 2D strain echocardiography were collected. Univariate logistic model was used in myocardial performance index (MPI) and /' analysis. Univariate and Multivariate logistic model were used in NLR analysis.
At baseline, all patients had normal left ventricular ejection fraction (LVEF). The myocardial performance index (MPI) (OR = 1.218 (95%CI 1.040, 1.426); = 0.0142) and /' (OR = 1.364 (95%CI 1.124, 1.655); = 0.0017) were independently associated with CRP. LSG led to a significant decrease in inflammatory markers (NLR, 2.4 ± 1.59 vs.1.7 ± 0.86; CRP, 5.6 ± 3.17 vs. 2.1 ± 2.35 mg/L, respectively, both < 0.001),which was more in NLR among female than male (OR = 3.14 (95%CI 1.112, 8.870); = 0.031).
The present study indicated a significant correlation between subclinical cardiac dysfunction and CRP among obese patients. Furthermore, female patients might benefit more from bariatric surgery on inflammation.
减重手术是治疗重度肥胖及其相关合并症的有效方法，炎症在其中起关键作用。本研究旨在调查接受腹腔镜袖状胃切除术（LSG）患者的中性粒细胞与淋巴细胞比值（NLR）和C反应蛋白（CRP）的变化，并探讨包括性别在内的相关因素。
我们回顾性纳入了2017年至2020年在我院接受LSG的72例患者。收集临床信息、实验室检查以及传统二维应变超声心动图得出的参数。心肌性能指数（MPI）和/'分析采用单因素逻辑模型。NLR分析采用单因素和多因素逻辑模型。
基线时，所有患者左心室射血分数（LVEF）均正常。心肌性能指数（MPI）（OR = 1.218（95%CI 1.040，1.426）； = 0.0142）和/'（OR = 1.364（95%CI 1.124，1.655）； = 0.0017）与CRP独立相关。LSG导致炎症标志物显著降低（NLR分别为2.4±1.59 vs.1.7±0.86；CRP分别为5.6±3.17 vs. 2.1±2.35mg/L，均<0.001），女性的NLR下降幅度大于男性（OR = 3.14（95%CI 1.112，8.870）； = 0.031）。
本研究表明肥胖患者亚临床心脏功能障碍与CRP之间存在显著相关性。此外，女性患者可能从减重手术对炎症的改善中获益更多。
